Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 10/20 | 0.72 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.64 |
| ▸ | CA12 | O43570 | 2/20 | 0.53 |
| ▸ | CA1 | P00915 | 2/20 | 0.53 |
| ▸ | CA2 | P00918 | 2/20 | 0.53 |
| ▸ | CA7 | P43166 | 2/20 | 0.53 |
| ▸ | CA9 | Q16790 | 2/20 | 0.53 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.53 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.53 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.48 |
| ▸ | SPR | P35270 | 1/20 | 0.47 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.47 |
| ▸ | HTR3B | O95264 | 1/20 | 0.47 |
| ▸ | HTR3A | P46098 | 1/20 | 0.47 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.47 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31048762 | 1.00 | NR4A2 (0.72) | NR4A2CREBBPCA12CA1CA2 | |
| SCHEMBL2084098 | 0.84 | NR4A2 (0.60) | NR4A2CREBBPCA12CA1CA2 | |
| SCHEMBL6418495 | 0.84 | NR4A2 (0.72) | NR4A2CREBBPNPC1MAPT | |
| SCHEMBL6588128 | 0.84 | NR4A2 (1.00) | NR4A2CREBBPNPC1MAPTMAP2K1 | |
| SCHEMBL1696922 | 0.83 | NR4A2 (0.51) | NR4A2CREBBPMAPTHTR3EHTR3B | |
| SCHEMBL5245797 | 0.83 | CA12 (0.56) | NR4A2CA12CA1CA2CA7 | |
| SCHEMBL5631381 | 0.83 | NR4A2 (0.70) | NR4A2CREBBPNPC1MAPTMAP2K1 | |
| SCHEMBL3094622 | 0.83 | NR4A2 (1.00) | NR4A2CREBBPNPC1MAPT | |
| SCHEMBL31501108 | 0.83 | NR4A2 (0.78) | NR4A2CREBBPNPC1MAPT | |
| SCHEMBL4236223 | 0.83 | NR4A2 (0.78) | NR4A2CREBBPNPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1428514-B1 | Dyeing composition comprising a tertiary paraphenylenediamine containing a pyrrolidine, a tertiary paraphenylenediamine and a benzomorpholine coupler; method and use | OREAL (FR) | 2007-09-19 | — | — | EP | claimed |
| US-20040205903-A1 | Dyeing composition comprising a cationic pyrrolidine-based para-phenylenefiamine, a tertiary para-phenylenediamine and a benzomorpholine coupler, methods and uses | L'OREAL (FR) | 2004-10-21 | — | — | US | claimed |
| EP-0446132-B1 | Keratinous fibres dyeing process with 6 or 7-monohydroxyindols at acidic pH and compositions | OREAL (FR) | 1994-09-14 | — | — | EP | claimed |
| US-5279620-A | Containg paraphenylenediamine, para-aminophenol and paraheterocyclic precursors | L'OREAL (FR) | 1994-01-18 | — | — | US | claimed |
| EP-0446132-A1 | Keratinous fibres dyeing process with 6 or 7-monohydroxyindols at acidic pH and compositions | L'OREAL (FR) | 1991-09-11 | — | — | EP | claimed |
| EP-0360638-A1 | Process for dyeing keratinous fibres with an indole derivative associated with a nitrite, and composition therefor | L'OREAL (FR) | 1990-03-28 | — | — | EP | claimed |
| CN-118615282-B | Radix clematidis alkaloid compound and application thereof | 广州华腾生物医药科技有限公司 | 2024-10-25 | — | — | CN | disclosed |
| CN-118615282-A | Radix clematidis alkaloid compound and application thereof | 广州华腾生物医药科技有限公司 | 2024-09-10 | — | — | CN | disclosed |
| US-20120172386-A1 | Combinations Comprising a VEGF Receptor Inhibitor | NOVARTIS AG (CH) | 2012-07-05 | — | — | US | disclosed |
| EP-1945217-B1 | COMBINATIONS COMPRISING A VEGF RECEPTOR INHIBITOR AND A PENETRATION ENHANCER | NOVARTIS AG (CH) | 2012-05-02 | — | — | EP | disclosed |
| US-20110301157-A1 | BICYCLIC AMIDES AS KINASE INHIBITORS | NOVARTIS AG | 2011-12-08 | — | — | US | disclosed |
| US-8026247-B2 | Bicyclic amides as kinase inhibitors | NOVARTIS AG (CH) | 2011-09-27 | — | — | US | disclosed |
| CN-101693709-A | Bicyclic amides as kinase inhibitors | NOVARTIS AG | 2010-04-14 | — | — | CN | disclosed |
| WO-2006059234-A2 | BICYCLIC AMIDES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2006-06-08 | — | — | WO | disclosed |
| US-20040205903-A1 | Dyeing composition comprising a cationic pyrrolidine-based para-phenylenefiamine, a tertiary para-phenylenediamine and a benzomorpholine coupler, methods and uses | L'OREAL (FR) | 2004-10-21 | — | — | US | disclosed |
| EP-0446132-B1 | Keratinous fibres dyeing process with 6 or 7-monohydroxyindols at acidic pH and compositions | OREAL (FR) | 1994-09-14 | — | — | EP | disclosed |
| US-5279620-A | Containg paraphenylenediamine, para-aminophenol and paraheterocyclic precursors | L'OREAL (FR) | 1994-01-18 | — | — | US | disclosed |
| US-5207798-A | Hair dyes | L'OREAL (FR) | 1993-05-04 | — | — | US | disclosed |
| EP-0446132-A1 | Keratinous fibres dyeing process with 6 or 7-monohydroxyindols at acidic pH and compositions | L'OREAL (FR) | 1991-09-11 | — | — | EP | disclosed |
| EP-0360638-A1 | Process for dyeing keratinous fibres with an indole derivative associated with a nitrite, and composition therefor | L'OREAL (FR) | 1990-03-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040205903-A1 | Dyeing composition comprising a cationic pyrrolidine-based para-phenylenefiamine, a tertiary para-phenylenediamine and a benzomorpholine coupler, methods and uses | CDC73, KRT18, PAH | NR4A2 1543/4885CREBBP 2948/4885CA12 991/4885 |
| US-20110301157-A1 | BICYCLIC AMIDES AS KINASE INHIBITORS | MAP3K20, MAP3K1, MAP3K19 | NR4A2 3536/4885CREBBP 609/4885CA12 4348/4885 |
| US-20120172386-A1 | Combinations Comprising a VEGF Receptor Inhibitor | KDR, FLT4, FLT1 | NR4A2 227/4885CREBBP 2228/4885CA12 3603/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.