Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPRA | P18433 | 1/20 | 0.51 |
| ▸ | FDPS | P14324 | 1/20 | 0.47 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.45 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.45 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.45 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.45 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.45 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.45 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | LIN28A | Q9H9Z2 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL198454 | 0.79 | PTPRA (0.54) | PTPRAFDPSGRIN2DGRIN3BGRIN1 | |
| SCHEMBL31450615 | 0.79 | PTPRA (0.54) | PTPRAFDPSGRIN2DGRIN3BGRIN1 | |
| SCHEMBL11373564 | 0.77 | GRIN2D (0.54) | PTPRAFDPSGRIN2DGRIN3BGRIN1 | |
| SCHEMBL30500296 | 0.77 | PTPRA (0.56) | PTPRAFDPSGRIN2DGRIN3BGRIN1 | |
| SCHEMBL28643131 | 0.77 | PTPRA (0.56) | PTPRAFDPSGRIN2DGRIN3BGRIN1 | |
| SCHEMBL4310761 | 0.77 | PTPRA (0.56) | PTPRAFDPSGRIN2DGRIN3BGRIN1 | |
| SCHEMBL1039370 | 0.76 | PTPRA (0.59) | PTPRAFDPSGRIN2DGRIN3BGRIN1 | |
| SCHEMBL29785749 | 0.76 | PTPRA (0.59) | PTPRAFDPSGRIN2DGRIN3BGRIN1 | |
| SCHEMBL12532007 | 0.76 | PTPRA (0.59) | PTPRAFDPSGRIN2DGRIN3BGRIN1 | |
| SCHEMBL7979864 | 0.76 | PTPRA (0.59) | PTPRAFDPSGRIN2DGRIN3BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3700907-B1 | NOVEL PYRAZOLO-PYRROLO-PYRIMIDINE-DIONE DERIVATIVES AS P2X3 INHIBITORS | BAYER AG (DE) | 2022-03-09 | — | — | EP | disclosed |