Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ2 | O43526 | 1/20 | 0.58 |
| ▸ | NAAA | Q02083 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CPB1 | P15086 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30012315 | 1.00 | KCNQ2 (0.58) | KCNQ2NAAAGAAALDH1A1MEN1 | |
| SCHEMBL30010861 | 1.00 | KCNQ2 (0.58) | KCNQ2NAAAGAAALDH1A1MEN1 | |
| SCHEMBL17452291 | 1.00 | KCNQ2 (0.58) | KCNQ2NAAAGAAALDH1A1MEN1 | |
| SCHEMBL30012431 | 0.89 | KCNQ2 (0.61) | KCNQ2NAAAGAAALDH1A1MEN1 | |
| SCHEMBL17452287 | 0.89 | KCNQ2 (0.61) | KCNQ2NAAAGAAALDH1A1MEN1 | |
| SCHEMBL17452304 | 0.88 | KCNQ2 (0.58) | KCNQ2NAAAGAAALDH1A1TSHR | |
| SCHEMBL18798099 | 0.88 | KCNQ2 (0.58) | KCNQ2NAAAGAAALDH1A1TSHR | |
| SCHEMBL16062473 | 0.88 | KCNQ2 (0.58) | KCNQ2NAAAGAAALDH1A1MEN1 | |
| SCHEMBL19097082 | 0.86 | KCNQ2 (0.56) | KCNQ2NAAAGAAALDH1A1HTT | |
| SCHEMBL17452293 | 0.86 | KCNQ2 (0.56) | KCNQ2NAAAGAAALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3511323-B1 | 2,3-DISUBSTITUTED 1-ACYL-4-AMINO-1,2,3,4-TETRAHYDROQUINOLINE DERIVATIVES AND THEIR USE AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2022-03-02 | — | — | EP | disclosed |