SCHEMBL2434734

SCHEMBL2434734

Nc1cn(-c2cccc(C(F)(F)F)c2)nc1NC(=O)c1ccc(CN(Cc2cccnc2)C(=O)O)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 2/20 0.52
HIF1A Q16665 6/20 0.48
EPAS1 Q99814 6/20 0.48
ADORA3 P0DMS8 3/20 0.46
DDR1 Q08345 1/20 0.41
DDR2 Q16832 1/20 0.41
SORT1 Q99523 1/20 0.41
MEN1 O00255 1/20 0.41
TSHR P16473 1/20 0.41
KMT2A Q03164 1/20 0.41
UBE2M P61081 3/20 0.41
DCUN1D1 Q96GG9 3/20 0.41
HDAC3 O15379 1/20 0.40
HDAC4 P56524 1/20 0.40
HDAC7 Q8WUI4 1/20 0.40
HDAC2 Q92769 1/20 0.40
HDAC10 Q969S8 1/20 0.40
HDAC11 Q96DB2 1/20 0.40
HDAC8 Q9BY41 1/20 0.40
HDAC6 Q9UBN7 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2436516 0.90 HDAC1 (0.54) HDAC1HIF1AEPAS1ADORA3HDAC3
SCHEMBL2435440 0.89 HDAC1 (0.55) HDAC1HIF1AEPAS1MEN1KMT2A
SCHEMBL2435576 0.88 HDAC1 (0.60) HDAC1HIF1AEPAS1ADORA3KMT2A
SCHEMBL2435416 0.88 HDAC1 (0.54) HDAC1HIF1AEPAS1ADORA3HDAC3
SCHEMBL2436599 0.86 HDAC1 (0.53) HDAC1MEN1TSHRKMT2AHDAC3
SCHEMBL2440097 0.85 HDAC1 (0.56) HDAC1HIF1AEPAS1MEN1KMT2A
SCHEMBL2434545 0.85 HDAC1 (0.54) HDAC1HIF1AEPAS1ADORA3MEN1
SCHEMBL2435563 0.85 HDAC1 (0.56) HDAC1HIF1AEPAS1ADORA3MEN1
SCHEMBL2438648 0.84 HDAC1 (0.56) HDAC1HIF1AEPAS1ADORA3HDAC3
SCHEMBL2438671 0.83 HDAC1 (0.54) HDAC1HIF1AEPAS1ADORA3KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1945617-B1 HISTONE DEACETYLASE INHIBITORS WITH ARYL-PYRAZOLYL MOTIFS MERCK SHARP & DOHME (US) 2012-12-26 EP claimed
US-8026260-B2 Histone deacetylase inhibitors with aryl-pyrazolyl-motifs MERCK SHARP & DOHME CORP. (US) 2011-09-27 US claimed
US-8026260-B2 Histone deacetylase inhibitors with aryl-pyrazolyl-motifs MERCK SHARP & DOHME CORP. (US) 2011-09-27 US disclosed