Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.38 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24347813 | 0.90 | KDM1A (0.42) | ACSS2SMYD3KMT2AMAPTHTT | |
| SCHEMBL21172691 | 0.90 | KDM1A (0.42) | ACSS2SMYD3KMT2AMAPTHTT | |
| SCHEMBL21172977 | 0.87 | SMYD3 (0.40) | ACSS2SMYD3KMT2AMAPTBRD4 | |
| SCHEMBL24348466 | 0.87 | SMYD3 (0.39) | ACSS2SMYD3KMT2AMAPTCRBN | |
| SCHEMBL21172966 | 0.86 | SMYD3 (0.47) | ACSS2SMYD3KMT2ACRBN | |
| SCHEMBL24347563 | 0.86 | SMYD3 (0.47) | ACSS2SMYD3KMT2ACRBN | |
| SCHEMBL21172676 | 0.85 | MAPT (0.38) | KMT2AMAPTHTTBRD4HPGD | |
| SCHEMBL21172602 | 0.85 | MAPT (0.38) | KMT2AMAPTHTTBRD4HPGD | |
| SCHEMBL24348119 | 0.83 | SMYD3 (0.39) | SMYD3KMT2AMAPTBRD4CRBN | |
| SCHEMBL21172800 | 0.83 | TDP1 (0.41) | KMT2AMAPTSMN1; SMN2BRD4HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3511323-B1 | 2,3-DISUBSTITUTED 1-ACYL-4-AMINO-1,2,3,4-TETRAHYDROQUINOLINE DERIVATIVES AND THEIR USE AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2022-03-02 | — | — | EP | disclosed |