Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.48 |
| ▸ | TNF | P01375 | 2/20 | 0.47 |
| ▸ | NOD2 | Q9HC29 | 2/20 | 0.47 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.47 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.44 |
| ▸ | PKLR | P30613 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21172901 | 0.87 | NOTUM (0.47) | NOTUMTNFNOD2NOD1AADAT | |
| SCHEMBL21172811 | 0.85 | NOTUM (0.46) | NOTUMTNFNOD2NOD1AADAT | |
| SCHEMBL26079156 | 0.84 | NOTUM (0.64) | NOTUMTNFNOD2NOD1PKLR | |
| SCHEMBL21173009 | 0.84 | NOTUM (0.49) | NOTUMKMT2AMEN1 | |
| SCHEMBL21172524 | 0.84 | NOTUM (0.44) | NOTUMTNFNOD2NOD1PKLR | |
| SCHEMBL21172849 | 0.84 | NOTUM (0.44) | NOTUMTNFNOD2NOD1PKLR | |
| SCHEMBL21172566 | 0.84 | NOTUM (0.49) | NOTUMKMT2AMEN1 | |
| SCHEMBL24347574 | 0.83 | NOTUM (0.43) | NOTUMTNFNOD2NOD1AADAT | |
| SCHEMBL24348012 | 0.83 | KMT2A (0.45) | NOTUMTNFNOD2NOD1AADAT | |
| SCHEMBL21172581 | 0.82 | TDP1 (0.44) | NOTUMTNFNOD2NOD1PKLR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3511323-B1 | 2,3-DISUBSTITUTED 1-ACYL-4-AMINO-1,2,3,4-TETRAHYDROQUINOLINE DERIVATIVES AND THEIR USE AS BROMODOMAIN INHIBITORS | GLAXOSMITHKLINE IP NO 2 LTD (GB) | 2022-03-02 | — | — | EP | disclosed |