Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 5/20 | 0.74 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.56 |
| ▸ | AURKA | O14965 | 2/20 | 0.56 |
| ▸ | INCENP | Q9NQS7 | 2/20 | 0.56 |
| ▸ | TPX2 | Q9ULW0 | 2/20 | 0.56 |
| ▸ | IKBKB | O14920 | 2/20 | 0.53 |
| ▸ | CHUK | O15111 | 2/20 | 0.53 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.48 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.48 |
| ▸ | JAK2 | O60674 | 4/20 | 0.48 |
| ▸ | JAK3 | P52333 | 3/20 | 0.48 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | PAK4 | O96013 | 1/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.48 |
| ▸ | IGF1R | P08069 | 1/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
| ▸ | PRKACA | P17612 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL100305 | 0.86 | GRM4 (1.00) | GRM4AURKBAURKAINCENPTPX2 | |
| SCHEMBL100615 | 0.84 | GRM4 (0.62) | GRM4AURKBAURKAINCENPTPX2 | |
| Trifluoroacetic Acid SCHEMBL4092717 | 0.84 | GRM4 (0.81) | GRM4AURKBAURKAINCENPTPX2 | |
| SCHEMBL2436937 | 0.81 | GRM4 (0.61) | GRM4AURKBAURKAINCENPTPX2 | |
| SCHEMBL4791827 | 0.81 | IKBKB (0.76) | AURKBAURKAINCENPTPX2IKBKB | |
| Trifluoroacetic Acid SCHEMBL4082643 | 0.81 | GRM4 (0.57) | GRM4AURKBAURKAINCENPTPX2 | |
| SCHEMBL6123302 | 0.81 | GRM4 (0.77) | GRM4AURKBAURKAINCENPTPX2 | |
| Trifluoroacetic Acid SCHEMBL4096450 | 0.81 | GRM4 (0.62) | GRM4AURKBAURKAINCENPTPX2 | |
| SCHEMBL103032 | 0.81 | GRM4 (0.72) | GRM4AURKBAURKAINCENPTPX2 | |
| SCHEMBL2710540 | 0.79 | GRM4 (0.77) | GRM4HTR2BMTNR1AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343299-B9 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | INCYTE HOLDINGS CORP (US) | 2017-03-08 | — | — | EP | claimed |
| EP-2348023-B9 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | INCYTE HOLDINGS CORP (US) | 2017-03-08 | — | — | EP | claimed |
| EP-2343299-B1 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | INCYTE CORP (US) | 2015-11-04 | — | — | EP | claimed |
| EP-2348023-B1 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | INCYTE CORP (US) | 2015-05-06 | — | — | EP | claimed |
| EP-1966202-B1 | HETEROARYL SUBSTITUTED PYRROLO[2,3-B]PYRIDINES AND PYRROLO[2,3-B]PYRIMIDINES AS JANUS KINASE INHIBITORS | INCYTE CORP (US) | 2011-09-21 | — | — | EP | claimed |
| WO-2013173506-A2 | METHOD OF TREATING MUSCULAR DEGRADATION | RIGEL PHARMACEUTICALS, INC. (US) | 2013-11-21 | — | — | WO | disclosed |