Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 20/20 | 0.69 |
| ▸ | FLT1 | P17948 | 4/20 | 0.69 |
| ▸ | FLT4 | P35916 | 4/20 | 0.69 |
| ▸ | MAPK14 | Q16539 | 10/20 | 0.59 |
| ▸ | TNNI3K | Q59H18 | 10/20 | 0.59 |
| ▸ | BRAF | P15056 | 9/20 | 0.59 |
| ▸ | RET | P07949 | 2/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.54 |
| ▸ | KIT | P10721 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2432354 | 0.91 | KDR (0.56) | KDRFLT1FLT4MAPK14TNNI3K | |
| SCHEMBL2431002 | 0.90 | KDR (0.72) | KDRFLT1FLT4MAPK14TNNI3K | |
| SCHEMBL2431516 | 0.88 | KDR (0.70) | KDRFLT1FLT4MAPK14TNNI3K | |
| SCHEMBL2434062 | 0.81 | KDR (1.00) | KDRFLT1FLT4MAPK14TNNI3K | |
| SCHEMBL2436450 | 0.80 | KDR (0.58) | KDRFLT1FLT4MAPK14TNNI3K | |
| SCHEMBL2433803 | 0.79 | KDR (0.74) | KDRFLT1FLT4MAPK14TNNI3K | |
| SCHEMBL2434118 | 0.79 | LRRK2 (0.49) | — | |
| SCHEMBL2706823 | 0.79 | KDR (0.42) | KDRFLT1FLT4MAPK14TNNI3K | |
| SCHEMBL2434216 | 0.78 | P2RX1 (0.52) | — | |
| SCHEMBL2437183 | 0.77 | KDR (0.78) | KDRFLT1FLT4MAPK14TNNI3K |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8026247-B2 | Bicyclic amides as kinase inhibitors | NOVARTIS AG (CH) | 2011-09-27 | — | — | US | disclosed |