Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.69 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.69 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.69 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.69 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.69 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.69 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.69 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.69 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.69 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.69 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.69 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.67 |
| ▸ | PRKACA | P17612 | 1/20 | 0.60 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.60 |
| ▸ | APP | P05067 | 1/20 | 0.55 |
| ▸ | MMP2 | P08253 | 1/20 | 0.55 |
| ▸ | MMP8 | P22894 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24359615 | 0.91 | HDAC1 (0.67) | HDAC1HDAC2HDAC6HDAC3HDAC4 | |
| SCHEMBL29516173 | 0.90 | HDAC1 (0.66) | HDAC1HDAC2HDAC6HDAC3HDAC4 | |
| SCHEMBL24359383 | 0.86 | HDAC1 (0.70) | HDAC1HDAC2HDAC6HDAC3HDAC4 | |
| SCHEMBL24359499 | 0.84 | HDAC1 (0.74) | HDAC1HDAC2HDAC6HDAC3HDAC4 | |
| SCHEMBL7996639 | 0.84 | HDAC1 (0.67) | HDAC1HDAC2HDAC6HDAC3HDAC4 | |
| SCHEMBL24359498 | 0.84 | HDAC1 (0.67) | HDAC1HDAC2HDAC6HDAC3HDAC4 | |
| SCHEMBL24359496 | 0.84 | HDAC1 (0.67) | HDAC1HDAC2HDAC6HDAC3HDAC4 | |
| SCHEMBL29516151 | 0.84 | HDAC1 (0.61) | HDAC1HDAC2HDAC6HDAC3HDAC4 | |
| SCHEMBL29516414 | 0.84 | HDAC1 (0.61) | HDAC1HDAC2HDAC6HDAC3HDAC4 | |
| SCHEMBL29516132 | 0.84 | HDAC1 (0.64) | HDAC1HDAC2HDAC6HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022087456-A1 | NEW COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2022-04-28 | — | — | WO | disclosed |
| WO-2022087456-A1 | NEW COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2022-04-28 | — | — | WO | disclosed |