Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 13/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.49 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.45 |
| ▸ | MTOR | P42345 | 4/20 | 0.40 |
| ▸ | PRKDC | P78527 | 3/20 | 0.40 |
| ▸ | PRKCI | P41743 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3610045 | 0.78 | PIK3CD (0.63) | PIK3CDCYP3A4PIK3CAPIK3R1PIK3CB | |
| SCHEMBL1194318 | 0.77 | PIK3CD (0.75) | PIK3CDCYP3A4PIK3CAPIK3R1PIK3CB | |
| SCHEMBL2463489 | 0.75 | PIK3CD (0.79) | PIK3CDCYP3A4PIK3CAPIK3R1PIK3CB | |
| SCHEMBL4069888 | 0.72 | HTR2C (0.51) | MAPT | |
| SCHEMBL1195266 | 0.72 | PIK3CD (0.68) | PIK3CDCYP3A4PIK3CAPIK3R1PIK3CB | |
| SCHEMBL1309842 | 0.72 | PIK3CD (0.59) | PIK3CDCYP3A4PIK3CAPIK3R1PIK3CB | |
| SCHEMBL30725653 | 0.72 | PIK3CD (0.62) | PIK3CDCYP3A4PIK3CAPIK3R1PIK3CB | |
| SCHEMBL13641103 | 0.71 | PIK3CD (0.56) | PIK3CDCYP3A4PIK3CAPIK3R1PIK3CB | |
| SCHEMBL13983595 | 0.71 | PIK3CD (0.62) | PIK3CDCYP3A4PIK3CAPIK3R1PIK3CB | |
| SCHEMBL13640270 | 0.69 | PIK3CD (0.82) | PIK3CDCYP3A4PIK3CAPIK3R1PIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2365810-A2 | PHOSPHATIDYLINOSITOL-3-KINASE P110 DELTA-TARGETED DRUGS IN THE TREATMENT OF CNS DISORDERS | The U.S.A. As Represented By The Secretary, Department Of Health And Human Services (US) | 2011-09-21 | — | — | EP | disclosed |
| WO-2010065923-A2 | PHOSPHATIDYLINOSITOL-3-KINASE P110 DELTA-TARGETED DRUGS IN THE TREATMENT OF CNS DISORDERS | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2010-06-10 | — | — | WO | disclosed |