Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 19/20 | 0.83 |
| ▸ | FLT1 | P17948 | 5/20 | 0.83 |
| ▸ | FLT4 | P35916 | 5/20 | 0.83 |
| ▸ | RET | P07949 | 2/20 | 0.75 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.75 |
| ▸ | KIT | P10721 | 2/20 | 0.75 |
| ▸ | RAF1 | P04049 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2435814 | 0.92 | KDR (0.87) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL274763 | 0.91 | KDR (1.00) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL2435183 | 0.90 | KDR (0.83) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL2430926 | 0.90 | KDR (0.78) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL2748395 | 0.88 | KDR (0.75) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL4548786 | 0.87 | KDR (0.74) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL4548722 | 0.86 | KDR (0.68) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL29525857 | 0.86 | KDR (1.00) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL2433509 | 0.86 | KDR (1.00) | KDRFLT1FLT4RETPDGFRB | |
| SCHEMBL2748337 | 0.85 | KDR (0.68) | KDRFLT1FLT4RETPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8026247-B2 | Bicyclic amides as kinase inhibitors | NOVARTIS AG (CH) | 2011-09-27 | — | — | US | disclosed |