Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPAS1 | Q99814 | 1/20 | 0.41 |
| ▸ | MBTD1 | Q05BQ5 | 3/20 | 0.39 |
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MLNR | O43193 | 1/20 | 0.31 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | FYN | P06241 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2898853 | 1.00 | EPAS1 (0.41) | EPAS1MBTD1L3MBTL3ALDH1A1OPRM1 | |
| SCHEMBL21567255 | 1.00 | EPAS1 (0.41) | EPAS1MBTD1L3MBTL3ALDH1A1OPRM1 | |
| SCHEMBL10477321 | 0.97 | EPAS1 (0.39) | EPAS1MBTD1L3MBTL3ALDH1A1OPRM1 | |
| SCHEMBL8603609 | 0.97 | EPAS1 (0.42) | EPAS1MBTD1L3MBTL3ALDH1A1OPRM1 | |
| SCHEMBL26720816 | 0.97 | EPAS1 (0.42) | EPAS1MBTD1L3MBTL3ALDH1A1OPRM1 | |
| SCHEMBL4783327 | 0.97 | EPAS1 (0.42) | EPAS1MBTD1L3MBTL3ALDH1A1OPRM1 | |
| SCHEMBL11570313 | 0.97 | EPAS1 (0.42) | EPAS1MBTD1L3MBTL3ALDH1A1OPRM1 | |
| SCHEMBL11570310 | 0.97 | EPAS1 (0.42) | EPAS1MBTD1L3MBTL3ALDH1A1OPRM1 | |
| SCHEMBL18790095 | 0.97 | EPAS1 (0.42) | EPAS1MBTD1L3MBTL3ALDH1A1OPRM1 | |
| SCHEMBL19303108 | 0.95 | EPAS1 (0.38) | EPAS1MBTD1L3MBTL3ALDH1A1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240228478-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. | 2024-07-11 | — | — | US | disclosed |
| US-20220127256-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. | 2022-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220127256-A1 | COMPOUNDS AND METHODS OF USE | F12, C1R, ABCG2 | EPAS1 4102/4885MBTD1 4349/4885L3MBTL3 2843/4885 |
| US-20240228478-A1 | COMPOUNDS AND METHODS OF USE | F12, C1R, ABCG2 | EPAS1 4102/4885MBTD1 4349/4885L3MBTL3 2843/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.