Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 6/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.59 |
| ▸ | CPS1 | P31327 | 4/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.48 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6450819 | 1.00 | GAA (0.62) | GAAMAPTHPGDALDH1A1LMNA | |
| SCHEMBL2107584 | 0.84 | ABCG2 (0.65) | MAPTHPGDALDH1A1LMNAMEN1 | |
| SCHEMBL30904861 | 0.84 | ABCG2 (0.65) | MAPTHPGDALDH1A1LMNAMEN1 | |
| SCHEMBL12722743 | 0.84 | ABCG2 (0.67) | MAPTHPGDALDH1A1LMNAMEN1 | |
| SCHEMBL5808359 | 0.84 | ABCG2 (0.67) | MAPTHPGDALDH1A1LMNAMEN1 | |
| SCHEMBL29246799 | 0.84 | MAPT (0.60) | GAAMAPTHPGDALDH1A1LMNA | |
| SCHEMBL5808361 | 0.84 | ABCG2 (0.67) | MAPTHPGDALDH1A1LMNAMEN1 | |
| SCHEMBL2107582 | 0.84 | ABCG2 (0.65) | MAPTHPGDALDH1A1LMNAMEN1 | |
| SCHEMBL29690463 | 0.84 | ABCG2 (0.65) | MAPTHPGDALDH1A1LMNAMEN1 | |
| SCHEMBL12722749 | 0.84 | ABCG2 (0.65) | MAPTHPGDALDH1A1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11827640-B2 | Substituted pyrazolo[1,5-a]pyrimidines as CFTR modulators | ILDONG PHARMACEUTICAL CO., LTD. (KR) | 2023-11-28 | — | — | US | disclosed |
| US-11827640-B2 | Substituted pyrazolo[1,5-a]pyrimidines as CFTR modulators | ILDONG PHARMACEUTICAL CO., LTD. (KR) | 2023-11-28 | — | — | US | disclosed |
| EP-4232451-A1 | CFTR MODULATOR COMPOUNDS, COMPOSITIONS, AND USES THEREOF | Ildong Pharmaceutical Co., Ltd. (KR) | 2023-08-30 | — | — | EP | disclosed |
| CN-116348468-A | CFTR modulator compounds, compositions and uses thereof | 日东制药株式会社 | 2023-06-27 | — | — | CN | disclosed |
| WO-2023067388-A1 | USES OF CFTR MODULATOR AND/OR PDE4 INHIBITOR COMPOUNDS | ILDONG PHARMACEUTICAL CO., LTD. (KR) | 2023-04-27 | — | — | WO | disclosed |
| WO-2022084741-A1 | CFTR MODULATOR COMPOUNDS, COMPOSITIONS, AND USES THEREOF | ILDONG PHARMACEUTICAL CO., LTD. (KR) | 2022-04-28 | — | — | WO | disclosed |
| WO-2022084741-A1 | CFTR MODULATOR COMPOUNDS, COMPOSITIONS, AND USES THEREOF | ILDONG PHARMACEUTICAL CO., LTD. (KR) | 2022-04-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11827640-B2 | Substituted pyrazolo[1,5-a]pyrimidines as CFTR modulators | PDE4A, PDE4B, PDE5A | GAA 447/4885MAPT 4661/4885HPGD 312/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.