Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.34 |
| ▸ | ESR1 | P03372 | 2/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3724473 | 0.82 | ESR1 (0.38) | APPTRPV1NR1H2NR1H3ESR1 | |
| SCHEMBL19426802 | 0.78 | TSHR (0.46) | NR1H2NR1H3ESR1ESR2NPC1 | |
| SCHEMBL11922 | 0.76 | CA1 (0.42) | TRPV1NR1H2NR1H3ESR1ESR2 | |
| SCHEMBL17080489 | 0.76 | TRPV1 (0.39) | APPTRPV1NR1H2NR1H3ESR1 | |
| SCHEMBL8327958 | 0.76 | CYP19A1 (0.46) | ESR1ESR2 | |
| SCHEMBL16546589 | 0.76 | CNR2 (0.41) | ESR1ESR2 | |
| SCHEMBL13440 | 0.75 | TSHR (0.50) | — | |
| SCHEMBL13016 | 0.75 | NPC1 (0.50) | APPESR1ESR2NPC1MAPT | |
| SCHEMBL22671428 | 0.74 | IDO1 (0.33) | MAPTRAB9A | |
| Iodide SCHEMBL5175074 | 0.73 | NPC1 (0.48) | APPNPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3988547-A1 | INDAZOLE DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL APPLICATION THEREOF | Jiangsu Hengrui Medicine Co., Ltd. (CN) | 2022-04-27 | — | — | EP | disclosed |