Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 18/20 | 1.00 |
| ▸ | IRAK1 | P51617 | 3/20 | 0.67 |
| ▸ | MTOR | P42345 | 1/20 | 0.67 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.65 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.65 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.65 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.65 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.65 |
| ▸ | CDK1 | P06493 | 1/20 | 0.65 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.65 |
| ▸ | MARK3 | P27448 | 1/20 | 0.65 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.65 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.65 |
| ▸ | CLK2 | P49760 | 1/20 | 0.65 |
| ▸ | GSK3B | P49841 | 1/20 | 0.65 |
| ▸ | NEK4 | P51957 | 1/20 | 0.65 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.65 |
| ▸ | ITK | Q08881 | 1/20 | 0.65 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.65 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25956617 | 0.87 | IRAK4 (0.83) | IRAK4IRAK1MTORDYRK3ROCK2 | |
| SCHEMBL26938119 | 0.85 | IRAK4 (0.74) | IRAK4IRAK1MTORDYRK3ROCK2 | |
| SCHEMBL169834 | 0.81 | IRAK4 (0.71) | IRAK4IRAK1MTORDYRK3ROCK2 | |
| SCHEMBL25956610 | 0.81 | IRAK4 (1.00) | IRAK4IRAK1MTORDYRK3ROCK2 | |
| SCHEMBL3600534 | 0.80 | IRAK4 (1.00) | IRAK4IRAK1MTORDYRK3ROCK2 | |
| SCHEMBL29363239 | 0.80 | IRAK4 (1.00) | IRAK4IRAK1MTORDYRK3ROCK2 | |
| SCHEMBL25956635 | 0.80 | IRAK4 (0.81) | IRAK4IRAK1MTORDYRK3ROCK2 | |
| SCHEMBL25956628 | 0.80 | IRAK4 (1.00) | IRAK4IRAK1MTORDYRK3ROCK2 | |
| SCHEMBL29827291 | 0.80 | IRAK4 (0.89) | IRAK4IRAK1MTORDYRK3ROCK2 | |
| SCHEMBL25956620 | 0.80 | IRAK4 (0.89) | IRAK4IRAK1MTORDYRK3ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11723980-B2 | IRAK degraders and uses thereof | KYMERA THERAPEUTICS, INC. (US) | 2023-08-15 | — | — | US | disclosed |
| US-20230132715-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2023-05-04 | — | — | US | disclosed |
| WO-2022087216-A1 | DOUBLE DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2022-04-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230132715-A1 | IRAK DEGRADERS AND USES THEREOF | IRAK2, IRAK3, IRAK1 | IRAK4 4/4885IRAK1 3/4885MTOR 1433/4885 |
| US-11723980-B2 | IRAK degraders and uses thereof | IRAK2, IRAK3, IRAK1 | IRAK4 4/4885IRAK1 3/4885MTOR 1433/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.