SCHEMBL24376827

SCHEMBL24376827

Cc1cc2c(cc1Sc1nc3c(N)ncnc3n1CCC(N)=O)CCC2

nearest known ligand 0.52

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 14/20 0.52
HSP90AB1 P08238 13/20 0.52
HSP90B1 P14625 7/20 0.49
TRAP1 Q12931 3/20 0.49
HDAC3 O15379 1/20 0.45
HDAC4 P56524 1/20 0.45
HDAC1 Q13547 1/20 0.45
HDAC7 Q8WUI4 1/20 0.45
HDAC2 Q92769 1/20 0.45
HDAC10 Q969S8 1/20 0.45
HDAC11 Q96DB2 1/20 0.45
HDAC8 Q9BY41 1/20 0.45
HDAC6 Q9UBN7 1/20 0.45
HDAC9 Q9UKV0 1/20 0.45
HDAC5 Q9UQL6 1/20 0.45
ERBB2 P04626 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13193761 0.89 HSP90AA1 (0.53) HSP90AA1HSP90AB1HSP90B1TRAP1HDAC3
SCHEMBL24377288 0.88 HSP90AA1 (0.49) HSP90AA1HSP90AB1HSP90B1TRAP1HDAC3
SCHEMBL24376739 0.87 HSP90AA1 (0.57) HSP90AA1HSP90AB1HSP90B1TRAP1HDAC3
SCHEMBL24376820 0.85 HSP90AA1 (0.52) HSP90AA1HSP90AB1HSP90B1TRAP1ERBB2
SCHEMBL1672618 0.83 HSP90AA1 (0.54) HSP90AA1HSP90AB1HSP90B1TRAP1HDAC3
SCHEMBL24377247 0.82 HSP90AA1 (0.50) HSP90AA1HSP90AB1HSP90B1TRAP1HDAC3
SCHEMBL24377284 0.82 HSP90AA1 (0.50) HSP90AA1HSP90AB1HSP90B1TRAP1HDAC3
SCHEMBL11908472 0.81 HSP90AA1 (0.54) HSP90AA1HSP90AB1HSP90B1TRAP1HDAC3
SCHEMBL24376867 0.80 HSP90AA1 (0.49) HSP90AA1HSP90AB1HSP90B1TRAP1HDAC3
SCHEMBL15610083 0.80 HSP90AB1 (0.54) HSP90AA1HSP90AB1HSP90B1TRAP1HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2694505-B1 HSP90 INHIBITORS SLOAN KETTERING INST CANCER RES (US) 2022-04-27 EP disclosed