Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 6/20 | 0.34 |
| ▸ | RET | P07949 | 2/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | ITK | Q08881 | 2/20 | 0.34 |
| ▸ | MERTK | Q12866 | 2/20 | 0.34 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.34 |
| ▸ | MAP3K6 | O95382 | 2/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.32 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.32 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | CLK1 | P49759 | 1/20 | 0.31 |
| ▸ | CLK2 | P49760 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2122234 | 0.75 | DYRK1A (0.42) | MAPTBRD4 | |
| SCHEMBL24834491 | 0.73 | NPC1 (0.52) | MAP3K5APPMAPT | |
| SCHEMBL758877 | 0.72 | PTGS1 (0.47) | MAPT | |
| Hydrochloric Acid SCHEMBL28842904 | 0.72 | NPC1 (0.50) | MAP3K5CSNK1DCSNK1G2APPMAPT | |
| SCHEMBL10807238 | 0.72 | MAPT (0.37) | APPMAPT | |
| SCHEMBL30170384 | 0.71 | PIK3CG (0.50) | RETMAPT | |
| SCHEMBL18782728 | 0.71 | HDAC8 (0.32) | — | |
| SCHEMBL3030493 | 0.71 | — | — | |
| SCHEMBL12335783 | 0.70 | KDM4E (0.36) | MAPT | |
| SCHEMBL25150638 | 0.70 | APP (0.32) | APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022086986-A1 | TREATMENT OF HEMATOLOGICAL MALIGNANCIES WITH INHIBITORS OF MENIN | KURA ONCOLOGY, INC. (US) | 2022-04-28 | — | — | WO | disclosed |