Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 12/20 | 0.68 |
| ▸ | BAD | Q92934 | 8/20 | 0.59 |
| ▸ | BCL2L1 | Q07817 | 7/20 | 0.59 |
| ▸ | BCL2 | P10415 | 5/20 | 0.55 |
| ▸ | PMAIP1 | Q13794 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19635744 | 0.94 | MCL1 (0.60) | MCL1BADBCL2L1BCL2PMAIP1 | |
| SCHEMBL19615122 | 0.88 | MCL1 (0.86) | MCL1BADBCL2L1BCL2PMAIP1 | |
| SCHEMBL19635592 | 0.88 | MCL1 (0.69) | MCL1BADBCL2L1BCL2 | |
| SCHEMBL19635950 | 0.87 | MCL1 (0.75) | MCL1BADBCL2L1BCL2 | |
| SCHEMBL19615183 | 0.83 | MCL1 (0.77) | MCL1BADBCL2L1BCL2PMAIP1 | |
| SCHEMBL19635951 | 0.82 | MCL1 (0.47) | MCL1BADBCL2L1BCL2PMAIP1 | |
| SCHEMBL19615206 | 0.82 | MCL1 (0.86) | MCL1BADBCL2L1BCL2 | |
| SCHEMBL24594048 | 0.82 | MCL1 (0.62) | MCL1BADBCL2L1BCL2PMAIP1 | |
| SCHEMBL19635585 | 0.81 | MCL1 (0.72) | MCL1BADBCL2L1BCL2 | |
| SCHEMBL24594061 | 0.81 | MCL1 (0.80) | MCL1BADBCL2L1BCL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3458459-B1 | MACROCYCLIC INDOLE DERIVATIVES | BAYER AG (DE) | 2022-04-27 | — | — | EP | disclosed |