Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 15/20 | 0.58 |
| ▸ | BAD | Q92934 | 7/20 | 0.56 |
| ▸ | BCL2L1 | Q07817 | 5/20 | 0.56 |
| ▸ | BCL2 | P10415 | 4/20 | 0.55 |
| ▸ | ALB | P02768 | 1/20 | 0.53 |
| ▸ | PMAIP1 | Q13794 | 4/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24378276 | 0.95 | MCL1 (0.57) | MCL1BADBCL2L1BCL2ALB | |
| SCHEMBL19615311 | 0.90 | MCL1 (0.72) | MCL1BADBCL2L1BCL2ALB | |
| SCHEMBL19615070 | 0.89 | MCL1 (0.69) | MCL1BADBCL2L1BCL2ALB | |
| SCHEMBL19635185 | 0.89 | MCL1 (0.64) | MCL1BADBCL2L1BCL2ALB | |
| SCHEMBL19635134 | 0.89 | MCL1 (0.60) | MCL1BADBCL2L1BCL2ALB | |
| SCHEMBL19615154 | 0.88 | MCL1 (0.74) | MCL1BADBCL2L1BCL2ALB | |
| SCHEMBL19615229 | 0.87 | MCL1 (0.73) | MCL1BADBCL2L1BCL2PMAIP1 | |
| SCHEMBL19635628 | 0.87 | MCL1 (0.62) | MCL1BADBCL2L1BCL2ALB | |
| SCHEMBL19635422 | 0.86 | MCL1 (0.56) | MCL1BADBCL2L1BCL2ALB | |
| SCHEMBL19635419 | 0.86 | MCL1 (0.57) | MCL1BADBCL2L1BCL2ALB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3458459-B1 | MACROCYCLIC INDOLE DERIVATIVES | BAYER AG (DE) | 2022-04-27 | — | — | EP | disclosed |