Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 18/20 | 0.59 |
| ▸ | BCL2L1 | Q07817 | 3/20 | 0.46 |
| ▸ | BCL2 | P10415 | 3/20 | 0.46 |
| ▸ | BAD | Q92934 | 3/20 | 0.45 |
| ▸ | PMAIP1 | Q13794 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19634922 | 0.87 | MCL1 (0.77) | MCL1BCL2L1BCL2BADPMAIP1 | |
| SCHEMBL24594115 | 0.87 | MCL1 (0.78) | MCL1PMAIP1 | |
| SCHEMBL24594161 | 0.85 | MCL1 (0.78) | MCL1PMAIP1 | |
| SCHEMBL24378082 | 0.85 | MCL1 (0.53) | MCL1BCL2L1BCL2BADPMAIP1 | |
| SCHEMBL19635581 | 0.85 | MCL1 (0.78) | MCL1BCL2L1BCL2BADPMAIP1 | |
| SCHEMBL19635289 | 0.84 | MCL1 (0.51) | MCL1BCL2L1BCL2BADPMAIP1 | |
| SCHEMBL24594104 | 0.83 | MCL1 (0.68) | MCL1PMAIP1 | |
| SCHEMBL24594149 | 0.83 | MCL1 (0.69) | MCL1PMAIP1 | |
| SCHEMBL24594207 | 0.82 | MCL1 (0.67) | MCL1PMAIP1 | |
| SCHEMBL23111033 | 0.82 | MCL1 (0.87) | MCL1BCL2L1BADPMAIP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3458459-B1 | MACROCYCLIC INDOLE DERIVATIVES | BAYER AG (DE) | 2022-04-27 | — | — | EP | disclosed |