Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24378566 | 0.87 | KDM4E (0.41) | KDM4EHSD17B10GAAMAPK1HPGD | |
| SCHEMBL24378574 | 0.85 | KDM4E (0.40) | KDM4EHSD17B10GAAMAPK1HPGD | |
| SCHEMBL27006286 | 0.84 | KDM4E (0.48) | KDM4EHSD17B10GAAMAPK1HPGD | |
| SCHEMBL25270148 | 0.83 | KDM4E (0.48) | KDM4EHSD17B10GAAMAPK1HPGD | |
| SCHEMBL30481136 | 0.83 | KDM4E (0.48) | KDM4EHSD17B10GAAMAPK1HPGD | |
| SCHEMBL24378640 | 0.82 | KDM4E (0.48) | KDM4EHSD17B10GAAMAPK1HPGD | |
| SCHEMBL27009130 | 0.82 | KDM4E (0.42) | KDM4EHSD17B10GAAMAPK1HPGD | |
| SCHEMBL25268340 | 0.82 | HSD17B10 (0.43) | KDM4EHSD17B10GAAMAPK1HPGD | |
| SCHEMBL24378553 | 0.81 | KDM4E (0.41) | KDM4EHSD17B10GAAMAPK1HPGD | |
| SCHEMBL27009107 | 0.80 | KDM4E (0.42) | KDM4EHSD17B10GAAMAPK1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022086993-A1 | NOVEL INHIBITORS OF PIKFYVE AND METHODS USING SAME | TME THERAPEUTICS LLC (US) | 2022-04-28 | — | — | WO | disclosed |