Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 8/20 | 0.65 |
| ▸ | TLR7 | Q9NYK1 | 6/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21325634 | 1.00 | TLR8 (0.65) | TLR8TLR7KCNH2CYP1A2CYP2D6 | |
| SCHEMBL13975554 | 0.93 | KCNH2 (0.62) | TLR8TLR7KCNH2CYP1A2CYP2D6 | |
| SCHEMBL15502392 | 0.93 | KCNH2 (0.62) | TLR8TLR7KCNH2CYP1A2CYP2D6 | |
| SCHEMBL22958997 | 0.85 | KCNH2 (0.85) | TLR8TLR7KCNH2 | |
| SCHEMBL13975908 | 0.85 | KCNH2 (0.85) | TLR8TLR7KCNH2 | |
| SCHEMBL24384587 | 0.85 | KCNH2 (0.85) | TLR8TLR7KCNH2 | |
| SCHEMBL22958975 | 0.84 | KCNH2 (0.74) | TLR8TLR7KCNH2CYP2D6 | |
| SCHEMBL22958962 | 0.84 | TLR8 (0.68) | TLR8TLR7KCNH2 | |
| SCHEMBL24384568 | 0.84 | TLR8 (0.68) | TLR8TLR7KCNH2 | |
| SCHEMBL22959012 | 0.84 | KCNH2 (0.74) | TLR8TLR7KCNH2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4059924-A1 | 2,4-DIAMINOQUINAZOLINE DERIVATIVES AND MEDICAL USES THEREOF | Janssen Sciences Ireland Unlimited Company (IE) | 2022-09-21 | — | — | EP | disclosed |
| EP-3759083-B1 | 2,4-DIAMINOQUINAZOLINE DERIVATIVES AND USE THEREOF IN THE TREATMENT OF VIRUS INFECTIONS, CANCER OR ALLERGIES | JANSSEN SCIENCES IRELAND UNLIMITED CO (IE) | 2022-05-04 | — | — | EP | disclosed |