Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 11/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 6/20 | 0.31 |
| ▸ | CD63 | P08962 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29750202 | 1.00 | HCRTR2 (0.48) | HCRTR2PDE3BPDE3ASYKCD63 | |
| SCHEMBL24386929 | 0.92 | HCRTR2 (0.49) | HCRTR2PDE3BPDE3ASYKCD63 | |
| SCHEMBL24387024 | 0.90 | HCRTR2 (0.38) | HCRTR2SYK | |
| SCHEMBL24529568 | 0.89 | HCRTR2 (0.57) | HCRTR2PDE3BPDE3ASYKCD63 | |
| SCHEMBL24387658 | 0.89 | HCRTR2 (0.52) | HCRTR2PDE3BPDE3ASYKCD63 | |
| SCHEMBL24386975 | 0.89 | HCRTR2 (0.37) | HCRTR2 | |
| SCHEMBL24387389 | 0.89 | HCRTR2 (0.39) | HCRTR2 | |
| SCHEMBL24387383 | 0.88 | HCRTR2 (0.51) | HCRTR2PDE3BPDE3ASYK | |
| SCHEMBL29750020 | 0.88 | HCRTR2 (0.43) | HCRTR2PDE3BPDE3ASYK | |
| SCHEMBL29749888 | 0.86 | HCRTR2 (0.44) | HCRTR2PDE3BPDE3ASYKCD63 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4236938-A1 | MACROCYCLIC UREA OREXIN RECEPTOR AGONISTS | Merck Sharp & Dohme LLC (US) | 2023-09-06 | — | — | EP | disclosed |
| WO-2022094012-A1 | MACROCYCLIC UREA OREXIN RECEPTOR AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2022-05-05 | — | — | WO | disclosed |
| WO-2022094012-A1 | MACROCYCLIC UREA OREXIN RECEPTOR AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2022-05-05 | — | — | WO | disclosed |