Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.62 |
| ▸ | JAK3 | P52333 | 7/20 | 0.62 |
| ▸ | BTK | Q06187 | 4/20 | 0.62 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.60 |
| ▸ | JAK2 | O60674 | 3/20 | 0.59 |
| ▸ | BLK | P51451 | 2/20 | 0.59 |
| ▸ | BMX | P51813 | 2/20 | 0.59 |
| ▸ | JAK1 | P23458 | 1/20 | 0.58 |
| ▸ | TTK | P33981 | 1/20 | 0.58 |
| ▸ | ITK | Q08881 | 4/20 | 0.54 |
| ▸ | PLK4 | O00444 | 1/20 | 0.52 |
| ▸ | GAK | O14976 | 1/20 | 0.52 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.52 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
| ▸ | CTSC | P53634 | 1/20 | 0.52 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.52 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.52 |
| ▸ | DCLK3 | Q9C098 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29507849 | 1.00 | EGFR (0.62) | EGFRJAK3BTKMAP3K7MAPK1 | |
| SCHEMBL24388550 | 0.93 | EGFR (0.60) | EGFRJAK3BTKMAP3K7MAPK1 | |
| SCHEMBL29507939 | 0.93 | EGFR (0.60) | EGFRJAK3BTKMAP3K7MAPK1 | |
| SCHEMBL24388548 | 0.93 | EGFR (0.60) | EGFRJAK3BTKMAP3K7MAPK1 | |
| SCHEMBL29507915 | 0.93 | EGFR (0.60) | EGFRJAK3BTKMAP3K7MAPK1 | |
| SCHEMBL24392914 | 0.92 | EGFR (0.63) | EGFRJAK3BTKMAP3K7MAPK1 | |
| SCHEMBL29537924 | 0.92 | EGFR (0.63) | EGFRJAK3BTKMAP3K7MAPK1 | |
| SCHEMBL29507886 | 0.89 | JAK3 (0.62) | EGFRJAK3BTKMAP3K7MAPK1 | |
| SCHEMBL24388382 | 0.89 | JAK3 (0.62) | EGFRJAK3BTKMAP3K7MAPK1 | |
| SCHEMBL29250693 | 0.89 | EGFR (0.64) | EGFRJAK3BTKMAP3K7MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116710444-A | Pyrimidine compounds, compositions and pharmaceutical uses thereof | 缆图药品公司 | 2023-09-05 | — | — | CN | disclosed |
| WO-2022094355-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS, AND MEDICINAL APPLICATIONS THEREOF | LENGO THERAPEUTICS, INC. (US) | 2022-05-05 | — | — | WO | disclosed |