Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 9/20 | 0.60 |
| ▸ | JAK2 | O60674 | 4/20 | 0.54 |
| ▸ | JAK1 | P23458 | 4/20 | 0.54 |
| ▸ | TTK | P33981 | 2/20 | 0.54 |
| ▸ | MAP3K7 | O43318 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.51 |
| ▸ | BTK | Q06187 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 6/20 | 0.47 |
| ▸ | TYK2 | P29597 | 1/20 | 0.45 |
| ▸ | CDC7 | O00311 | 1/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | PAK4 | O96013 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | PRKACA | P17612 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29508098 | 1.00 | JAK3 (0.60) | JAK3JAK2JAK1TTKMAP3K7 | |
| SCHEMBL24388374 | 0.96 | JAK3 (0.61) | JAK3JAK2JAK1TTKMAP3K7 | |
| SCHEMBL29508109 | 0.96 | JAK3 (0.61) | JAK3JAK2JAK1TTKMAP3K7 | |
| SCHEMBL29508032 | 0.95 | JAK3 (0.60) | JAK3JAK2JAK1TTKMAP3K7 | |
| SCHEMBL24388367 | 0.95 | JAK3 (0.60) | JAK3JAK2JAK1TTKMAP3K7 | |
| SCHEMBL24388544 | 0.93 | JAK3 (0.58) | JAK3JAK2JAK1TTKMAP3K7 | |
| SCHEMBL29508045 | 0.93 | JAK3 (0.58) | JAK3JAK2JAK1TTKMAP3K7 | |
| SCHEMBL24388558 | 0.93 | JAK3 (0.58) | JAK3JAK2JAK1TTKMAP3K7 | |
| SCHEMBL29508086 | 0.93 | JAK3 (0.58) | JAK3JAK2JAK1TTKMAP3K7 | |
| SCHEMBL24392741 | 0.93 | JAK3 (0.60) | JAK3JAK2JAK1TTKMAP3K7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116710444-A | Pyrimidine compounds, compositions and pharmaceutical uses thereof | 缆图药品公司 | 2023-09-05 | — | — | CN | disclosed |
| WO-2022094355-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS, AND MEDICINAL APPLICATIONS THEREOF | LENGO THERAPEUTICS, INC. (US) | 2022-05-05 | — | — | WO | disclosed |