Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C2 | P08235 | 6/20 | 0.66 |
| ▸ | ELANE | P08246 | 4/20 | 0.39 |
| ▸ | PTPRC | P08575 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | AVPR2 | P30518 | 2/20 | 0.35 |
| ▸ | GPR27 | Q9NS67 | 2/20 | 0.35 |
| ▸ | PTGES | O14684 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1382292 | 0.87 | NR3C2 (0.72) | NR3C2ELANEPTPRCLMNAMAPT | |
| SCHEMBL2540736 | 0.86 | NR3C2 (0.79) | NR3C2ELANEPTPRCLMNAMAPT | |
| SCHEMBL2357954 | 0.86 | NR3C2 (0.79) | NR3C2ELANEPTPRCLMNAMAPT | |
| SCHEMBL2439584 | 0.83 | NR3C2 (0.79) | NR3C2PTPRCLMNAMAPTTDP1 | |
| SCHEMBL28178744 | 0.81 | NR3C2 (0.73) | NR3C2PTPRCLMNAMAPTTDP1 | |
| SCHEMBL4638193 | 0.81 | NR3C2 (0.39) | NR3C2ALDH1A1 | |
| SCHEMBL17646149 | 0.81 | NR3C2 (0.81) | NR3C2PTPRCLMNAMAPTTDP1 | |
| SCHEMBL29571805 | 0.80 | NR3C2 (1.00) | NR3C2PTPRCLMNAMAPTTDP1 | |
| SCHEMBL1381714 | 0.80 | NR3C2 (1.00) | NR3C2PTPRCLMNAMAPTTDP1 | |
| SCHEMBL2441069 | 0.79 | NR3C2 (0.71) | NR3C2PTPRCLMNAAVPR2GPR27 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8026237-B2 | For modulating activity of one or more steroid nuclear receptors and for treatment, prevention, or amelioration of symptoms of disease or disorder related to the activity of receptors; 5-benzo[b]thiophen-2-yl-1,4-dimethyl-1H-pyrrole-3-carboxylic acid (4-methanesulfonyl-phenyl)-amide | EXELIXIS, INC. (US) | 2011-09-27 | — | — | US | claimed |
| US-8026237-B2 | For modulating activity of one or more steroid nuclear receptors and for treatment, prevention, or amelioration of symptoms of disease or disorder related to the activity of receptors; 5-benzo[b]thiophen-2-yl-1,4-dimethyl-1H-pyrrole-3-carboxylic acid (4-methanesulfonyl-phenyl)-amide | EXELIXIS, INC. (US) | 2011-09-27 | — | — | US | disclosed |