Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAV | P06756 | 17/20 | 0.48 |
| ▸ | ITGB6 | P18564 | 15/20 | 0.48 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.48 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.48 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.48 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.48 |
| ▸ | ITGB8 | P26012 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL275989 | 1.00 | ITGAV (0.48) | ITGAVITGB6ITGB3ITGA5ITGB1 | |
| Trifluoroacetic Acid SCHEMBL3222689 | 0.97 | ITGAV (0.46) | ITGAVITGB6ITGB3ITGA5ITGB1 | |
| SCHEMBL275499 | 0.92 | ITGAV (0.43) | ITGAVITGB6ITGB3ITGA5ITGB1 | |
| SCHEMBL328214 | 0.86 | ITGAV (0.50) | ITGAVITGB6ITGB3ITGA5ITGB1 | |
| SCHEMBL328142 | 0.86 | ITGAV (0.50) | ITGAVITGB6ITGB3ITGA5ITGB1 | |
| SCHEMBL13003793 | 0.86 | ITGAV (0.50) | ITGAVITGB6ITGB3ITGA5ITGB1 | |
| SCHEMBL8268188 | 0.85 | ITGAV (0.52) | ITGAVITGB6ITGB3ITGA5ITGB1 | |
| SCHEMBL327985 | 0.85 | ITGAV (0.52) | ITGAVITGB6ITGB3ITGA5ITGB1 | |
| SCHEMBL328179 | 0.84 | ITGAV (0.53) | ITGAVITGB6ITGB3ITGA5ITGB1 | |
| SCHEMBL327992 | 0.84 | ITGAV (0.51) | ITGAVITGB6ITGB3ITGA5ITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1747222-B1 | PYRIMIDINE DERIVATIVES ANTAGONISTS OF VITRONECTIN RECEPTOR | GALAPAGOS NV (BE) | 2014-04-16 | — | — | EP | disclosed |
| EP-2368891-B1 | Pyrimidines derivatives as antagonists of the vitronectine receptors | GALAPAGOS NV (BE) | 2012-09-19 | — | — | EP | disclosed |
| EP-2368891-A1 | Pyrimidines derivatives as antagonists of the vitronectine receptors | Galapagos SAS (FR) | 2011-09-28 | — | — | EP | disclosed |
| EP-1747222-A1 | PYRIMIDINE DERIVATIVES ANTAGONISTS OF VITRONECTIN RECEPTOR | Proskelia SAS (FR) | 2007-01-31 | — | — | EP | disclosed |
| WO-2005123734-A1 | PYRIMIDINE DERIVATIVES ANTAGONISTS OF VITRONECTIN RECEPTOR | PROSKELIA SAS (FR) | 2005-12-29 | — | — | WO | disclosed |