SCHEMBL24404153

SCHEMBL24404153

CCC(=O)OCCOc1ccc(C2(c3ccc(N4CCOCC4)cc3)C=Cc3c4c(c5ccc(OC)cc5c3O2)-c2ccc(OC)cc2C42CCC3(CCCCC3)CC2)cc1

nearest known ligand 0.34

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.34
MRGPRX4 Q96LA9 1/20 0.31
ESR1 P03372 2/20 0.30
L3MBTL1 Q9Y468 1/20 0.30
ALDH1A1 P00352 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24605038 0.92 MAPT (0.33) MAPTMRGPRX4
SCHEMBL24604951 0.91 MAPT (0.33) MAPTMRGPRX4ESR1
SCHEMBL24404152 0.88 ATM (0.32) MAPTL3MBTL1ALDH1A1
SCHEMBL25696887 0.87 ATM (0.34) MAPTMRGPRX4ESR1
SCHEMBL22864324 0.85 ATM (0.34) MAPTL3MBTL1ALDH1A1
SCHEMBL24678318 0.85 MAPT (0.33) MAPTMRGPRX4ALDH1A1
SCHEMBL25090645 0.84 MAPT (0.35) MAPTMRGPRX4L3MBTL1ALDH1A1
SCHEMBL24605037 0.82 MAPT (0.33) MAPTL3MBTL1
SCHEMBL24605093 0.82 MAPT (0.33) MAPTL3MBTL1
SCHEMBL24678603 0.82 ATM (0.33) MAPTMRGPRX4ESR1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3995493-B1 CHROMENE COMPOUND AND PHOTOCHROMIC OPTICAL ARTICLE TOKUYAMA CORP (JP) 2024-07-03 EP disclosed
EP-3995493-A1 CHROMENE COMPOUND AND PHOTOCHROMIC OPTICAL ARTICLE Tokuyama Corporation (JP) 2022-05-11 EP disclosed