SCHEMBL2440639

SCHEMBL2440639

Cc1cc(OC(=O)Nc2noc3cccc(OCC(F)(F)F)c23)c(C)o1

nearest known ligand 0.38

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
SGMS2 Q8NHU3 9/20 0.38
SGMS1 Q86VZ5 4/20 0.36
POLB P06746 2/20 0.35
LCLAT1 Q6UWP7 4/20 0.35
KCNA5 P22460 1/20 0.35
ALDH1A1 P00352 2/20 0.34
KDM4E B2RXH2 1/20 0.34
NPC1 O15118 1/20 0.34
RAB9A P51151 1/20 0.34
IDO1 P14902 1/20 0.34
SGPL1 O95470 1/20 0.34
MAPT P10636 1/20 0.33
BLM P54132 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2449178 0.83 MEN1 (0.39) SGMS2SGMS1LCLAT1KCNA5ALDH1A1
Cyclohexane SCHEMBL2442882 0.79 KCNA5 (0.39) SGMS2SGMS1LCLAT1KCNA5MAPT
Cyclopropane SCHEMBL2441865 0.79 KCNA5 (0.39) SGMS2SGMS1LCLAT1KCNA5MAPT
SCHEMBL2442915 0.79 HIF1A (0.41) POLBLCLAT1SGPL1MAPT
SCHEMBL2442656 0.78 KCNA5 (0.40) SGMS2SGMS1KCNA5
SCHEMBL2439003 0.76 KDM4E (0.42) SGMS2SGMS1KCNA5KDM4EMAPT
SCHEMBL2437982 0.75 S1PR1 (0.49) SGMS2SGMS1LCLAT1KCNA5ALDH1A1
SCHEMBL2438849 0.75 SMN1; SMN2 (0.45) KCNA5NPC1RAB9AMAPTL3MBTL1
SCHEMBL2440764 0.74 TP53 (0.44) SGMS2LCLAT1MAPT
SCHEMBL2438284 0.74 KCNQ3 (0.46) SGMS2SGMS1LCLAT1KDM4ENPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1893589-B1 SUBSTITUTED N-BENZO [D] ISOXAZOL-3-YL-AMINE DERIVATIVES AS INHIBITORS OF MGLUR5, SEROTONINE (5-HT) AND NORADRENALINE RECEPTORS, AND THE USE THEREOF FOR PRODUCING MEDICAMENTS GRUENENTHAL GMBH (DE) 2011-09-14 EP claimed
EP-1893589-A1 SUBSTITUTED N-BENZO [D] ISOXAZOL-3-YL-AMINE DERIVATIVES AS INHIBITORS OF MGLUR5, SEROTONINE (5-HT) AND NORADRENALINE RECEPTORS, AND THE USE THEREOF FOR PRODUCING MEDICAMENTS Grünenthal GmbH (DE) 2008-03-05 EP claimed
WO-2006131296-A1 SUBSTITUTED N-BENZO [D] ISOXAZOL-3-YL-AMINE DERIVATIVES AS INHIBITORS OF MGLUR5, SEROTONINE (5-HT) AND NORADRENALINE RECEPTORS, AND THE USE THEREOF FOR PRODUCING MEDICAMENTS Grünenthal GmbH (DE) 2006-12-14 WO claimed
EP-1893589-B1 SUBSTITUTED N-BENZO [D] ISOXAZOL-3-YL-AMINE DERIVATIVES AS INHIBITORS OF MGLUR5, SEROTONINE (5-HT) AND NORADRENALINE RECEPTORS, AND THE USE THEREOF FOR PRODUCING MEDICAMENTS GRUENENTHAL GMBH (DE) 2011-09-14 EP disclosed
EP-1893589-A1 SUBSTITUTED N-BENZO [D] ISOXAZOL-3-YL-AMINE DERIVATIVES AS INHIBITORS OF MGLUR5, SEROTONINE (5-HT) AND NORADRENALINE RECEPTORS, AND THE USE THEREOF FOR PRODUCING MEDICAMENTS Grünenthal GmbH (DE) 2008-03-05 EP disclosed
WO-2006131296-A1 SUBSTITUTED N-BENZO [D] ISOXAZOL-3-YL-AMINE DERIVATIVES AS INHIBITORS OF MGLUR5, SEROTONINE (5-HT) AND NORADRENALINE RECEPTORS, AND THE USE THEREOF FOR PRODUCING MEDICAMENTS Grünenthal GmbH (DE) 2006-12-14 WO disclosed