Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 9/20 | 0.68 |
| ▸ | JAK2 | O60674 | 12/20 | 0.67 |
| ▸ | JAK3 | P52333 | 9/20 | 0.67 |
| ▸ | JAK1 | P23458 | 4/20 | 0.67 |
| ▸ | BRDT | Q58F21 | 3/20 | 0.67 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.67 |
| ▸ | AXL | P30530 | 2/20 | 0.67 |
| ▸ | MERTK | Q12866 | 2/20 | 0.67 |
| ▸ | RET | P07949 | 2/20 | 0.67 |
| ▸ | WEE1 | P30291 | 2/20 | 0.67 |
| ▸ | FLT3 | P36888 | 2/20 | 0.67 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.67 |
| ▸ | TYK2 | P29597 | 2/20 | 0.67 |
| ▸ | SRC | P12931 | 2/20 | 0.67 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.67 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.67 |
| ▸ | PLK4 | O00444 | 1/20 | 0.67 |
| ▸ | STK25 | O00506 | 1/20 | 0.67 |
| ▸ | CIT | O14578 | 1/20 | 0.67 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22932106 | 0.99 | BRD4 (0.67) | BRD4JAK2JAK3JAK1BRDT | |
| SCHEMBL22931699 | 0.95 | BRD4 (0.62) | BRD4JAK2JAK3JAK1BRDT | |
| SCHEMBL22931697 | 0.94 | BRD4 (0.59) | BRD4JAK2JAK3JAK1BRDT | |
| SCHEMBL22932103 | 0.94 | BRD4 (0.59) | BRD4JAK2JAK3JAK1BRDT | |
| SCHEMBL22932009 | 0.94 | BRD4 (0.59) | BRD4JAK2JAK3JAK1BRDT | |
| SCHEMBL22932114 | 0.93 | BRD4 (0.59) | BRD4JAK2JAK3JAK1BRDT | |
| SCHEMBL22931680 | 0.88 | BRD4 (0.51) | BRD4JAK2JAK3JAK1BRDT | |
| SCHEMBL22931678 | 0.85 | BRD4 (0.57) | BRD4JAK2JAK3JAK1BRDT | |
| SCHEMBL22932177 | 0.84 | BRD4 (0.52) | BRD4JAK2JAK3JAK1BRDT | |
| SCHEMBL24464308 | 0.84 | BRD4 (0.51) | BRD4JAK2JAK3JAK1BRDT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4006031-A1 | DIHYDRO-PYRROLO-PYRIMIDINE SELECTIVE JAK2 INHIBITOR | Shanghai Xunhe Pharmaceutical Technology Co. Ltd. (CN) | 2022-06-01 | — | — | EP | disclosed |
| US-20220144844-A1 | SELECTIVE DIHYDROPYRROLOPYRIMIDINE JAK2 INHIBITORS | Shanghai Xunhe Pharmaceutical Technology Co. Ltd. (CN) | 2022-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220144844-A1 | SELECTIVE DIHYDROPYRROLOPYRIMIDINE JAK2 INHIBITORS | JAK2, JAK1, JAK3 | BRD4 115/4885JAK2 1/4885JAK3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.