Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 16/20 | 0.77 |
| ▸ | EDNRB | P24530 | 8/20 | 0.76 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.73 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.73 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.73 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.73 |
| ▸ | DHPS | P49366 | 1/20 | 0.73 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.73 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2433977 | 0.91 | EDNRA (0.67) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL7598296 | 0.89 | EDNRA (0.79) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL7300165 | 0.88 | EDNRA (0.80) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL7298083 | 0.87 | EDNRA (1.00) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL7296746 | 0.87 | EDNRA (1.00) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL2441280 | 0.87 | EDNRA (0.84) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL8326901 | 0.87 | EDNRA (0.84) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL7582530 | 0.86 | EDNRA (0.84) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL9423836 | 0.86 | EDNRA (0.98) | EDNRAEDNRBABCC3ABCC4NR1I2 | |
| SCHEMBL7295188 | 0.86 | EDNRA (0.82) | EDNRAEDNRBABCC3ABCC4NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2550256-B1 | PROCESS FOR THE PREPARATION OF BOSENTAN | LESVI LABORATORIOS SL (ES) | 2015-07-15 | — | — | EP | disclosed |
| EP-2550256-A1 | PROCESS FOR THE PREPARATION OF BOSENTAN | Laboratorios Lesvi, S.L. (ES) | 2013-01-30 | — | — | EP | disclosed |
| WO-2011117143-A1 | PROCESS FOR THE PREPARATION OF BOSENTAN | LABORATORIOS LESVI, S.L. (ES) | 2011-09-29 | — | — | WO | disclosed |
| EP-2368884-A1 | Process for the preparation of bosentan | Laboratorios Lesvi, S.L. (ES) | 2011-09-28 | — | — | EP | disclosed |