Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 9/20 | 0.64 |
| ▸ | ACVRL1 | P37023 | 5/20 | 0.64 |
| ▸ | ACVR1B | P36896 | 5/20 | 0.64 |
| ▸ | BMPR1B | O00238 | 4/20 | 0.64 |
| ▸ | BMPR1A | P36894 | 3/20 | 0.64 |
| ▸ | KDR | P35968 | 7/20 | 0.50 |
| ▸ | FLT1 | P17948 | 4/20 | 0.50 |
| ▸ | FLT4 | P35916 | 3/20 | 0.50 |
| ▸ | PRKAB2 | O43741 | 3/20 | 0.48 |
| ▸ | BMP4 | P12644 | 3/20 | 0.48 |
| ▸ | PRKAG1 | P54619 | 3/20 | 0.48 |
| ▸ | PRKAA2 | P54646 | 3/20 | 0.48 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.48 |
| ▸ | PRKAG3 | Q9UGI9 | 3/20 | 0.48 |
| ▸ | PRKAG2 | Q9UGJ0 | 3/20 | 0.48 |
| ▸ | PRKAB1 | Q9Y478 | 3/20 | 0.48 |
| ▸ | LCK | P06239 | 2/20 | 0.48 |
| ▸ | SRC | P12931 | 2/20 | 0.48 |
| ▸ | YES1 | P07947 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24425053 | 0.93 | ACVR1 (0.64) | ACVR1ACVRL1ACVR1BBMPR1BBMPR1A | |
| SCHEMBL24409628 | 0.85 | FLT1 (0.69) | ACVR1ACVRL1ACVR1BBMPR1BBMPR1A | |
| SCHEMBL24409663 | 0.85 | ACVR1 (0.46) | ACVR1ACVRL1ACVR1BBMPR1BBMPR1A | |
| SCHEMBL19124902 | 0.85 | ACVR1 (0.64) | ACVR1ACVRL1ACVR1BBMPR1BBMPR1A | |
| SCHEMBL24412266 | 0.85 | ACVR1 (0.64) | ACVR1ACVRL1ACVR1BBMPR1BBMPR1A | |
| SCHEMBL24409700 | 0.84 | FLT1 (0.67) | ACVR1ACVRL1ACVR1BBMPR1BBMPR1A | |
| SCHEMBL24409701 | 0.84 | ACVR1 (0.45) | ACVR1ACVRL1ACVR1BBMPR1BBMPR1A | |
| SCHEMBL17442152 | 0.84 | ACVR1 (0.66) | ACVR1ACVRL1ACVR1BBMPR1BBMPR1A | |
| SCHEMBL24409654 | 0.84 | KDR (0.51) | ACVR1ACVRL1ACVR1BBMPR1BBMPR1A | |
| SCHEMBL17448559 | 0.84 | ACVR1 (0.72) | ACVR1ACVRL1ACVR1BBMPR1BBMPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023081212-A1 | METHODS OF USING ALK2 INHIBITORS | KEROS THERAPEUTICS, INC. (US) | 2023-05-11 | — | — | WO | disclosed |
| WO-2022099166-A1 | METHODS OF TREATING CARDIOVASCULAR-RELATED DISEASE | KEROS THERAPEUTICS, INC. (US) | 2022-05-12 | — | — | WO | disclosed |
| WO-2022098812-A1 | METHODS OF TREATING IRON OVERLOAD | KEROS THERAPEUTICS, INC. (US) | 2022-05-12 | — | — | WO | disclosed |
| WO-2022098821-A1 | METHODS OF TREATING LYMPHOPENIA | KEROS THERAPEUTICS, INC. (US) | 2022-05-12 | — | — | WO | disclosed |