Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.82 |
| ▸ | MTOR | P42345 | 20/20 | 0.82 |
| ▸ | PIK3CG | P48736 | 18/20 | 0.82 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL32474 | 0.90 | PIK3CA (1.00) | PIK3CAMTORPIK3CGPIK3R1 | |
| SCHEMBL2443055 | 0.89 | MTOR (0.83) | PIK3CAMTORPIK3CG | |
| SCHEMBL14629843 | 0.89 | PIK3CA (0.67) | PIK3CAMTORPIK3CG | |
| SCHEMBL2442143 | 0.84 | MTOR (0.58) | PIK3CAMTORPIK3CGPIK3R1 | |
| SCHEMBL2523945 | 0.84 | PIK3CA (0.87) | PIK3CAMTORPIK3CGPIK3R1 | |
| SCHEMBL1409937 | 0.83 | MTOR (0.85) | PIK3CAMTORPIK3CG | |
| SCHEMBL32345 | 0.82 | MTOR (0.85) | PIK3CAMTORPIK3CG | |
| SCHEMBL32161 | 0.82 | PIK3CA (1.00) | PIK3CAMTORPIK3CGPIK3R1 | |
| SCHEMBL2444210 | 0.82 | MTOR (0.85) | PIK3CAMTORPIK3CGPIK3R1 | |
| SCHEMBL32189 | 0.81 | MTOR (1.00) | PIK3CAMTORPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130040934-A1 | SPIROCYCLIC COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS AND DIAGNOSTIC PROBES | UNIVERSITY OF BASEL (CH) | 2013-02-14 | — | — | US | claimed |
| EP-2547684-A1 | SPIROCYCLIC COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS AND DIAGNOSTIC PROBES | University of Basel (CH) | 2013-01-23 | — | — | EP | claimed |
| WO-2011114275-A1 | SPIROCYCLIC COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS AND DIAGNOSTIC PROBES | UNIVERSITY OF BASEL (CH) | 2011-09-22 | — | — | WO | claimed |
| US-20130040934-A1 | SPIROCYCLIC COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS AND DIAGNOSTIC PROBES | UNIVERSITY OF BASEL (CH) | 2013-02-14 | — | — | US | disclosed |
| EP-2547684-A1 | SPIROCYCLIC COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS AND DIAGNOSTIC PROBES | University of Basel (CH) | 2013-01-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130040934-A1 | SPIROCYCLIC COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS AND DIAGNOSTIC PROBES | CDK4, GRK4, RPS6KA4 | PIK3CA 13/4885MTOR 6/4885PIK3CG 306/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.