Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 8/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 8/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 7/20 | 0.33 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | KDM5A | P29375 | 6/20 | 0.32 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.31 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | CTSA | P10619 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29584335 | 1.00 | TLR8 (0.33) | TLR8TLR7TLR9TBK1CHEK1 | |
| SCHEMBL24423697 | 1.00 | TLR8 (0.33) | TLR8TLR7TLR9TBK1CHEK1 | |
| SCHEMBL29585018 | 1.00 | TLR8 (0.33) | TLR8TLR7TLR9TBK1CHEK1 | |
| SCHEMBL24423698 | 1.00 | TLR8 (0.33) | TLR8TLR7TLR9TBK1CHEK1 | |
| SCHEMBL24423911 | 0.91 | FFAR4 (0.37) | TLR8TLR7TLR9TBK1KDM5A | |
| SCHEMBL29584891 | 0.91 | FFAR4 (0.37) | TLR8TLR7TLR9TBK1KDM5A | |
| SCHEMBL24424524 | 0.91 | FFAR4 (0.37) | TLR8TLR7TLR9TBK1KDM5A | |
| SCHEMBL24423469 | 0.91 | PDCD1 (0.31) | PDCD1CD274KDM4E | |
| SCHEMBL24424523 | 0.91 | FFAR4 (0.37) | TLR8TLR7TLR9TBK1KDM5A | |
| SCHEMBL29585040 | 0.91 | FFAR4 (0.37) | TLR8TLR7TLR9TBK1KDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116635380-A | PPARgamma modulators and methods of use | 卫材R&D管理有限公司 | 2023-08-22 | — | — | CN | disclosed |
| WO-2022099144-A1 | ΡΡΑRγ MODULATORS AND METHODS OF USE | Eisai R&D Mangement Co., Ltd. (JP) | 2022-05-12 | — | — | WO | disclosed |