Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 10/20 | 0.39 |
| ▸ | CETP | P11597 | 1/20 | 0.35 |
| ▸ | MME | P08473 | 2/20 | 0.34 |
| ▸ | ACE | P12821 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | FASN | P49327 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.33 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24380884 | 0.88 | FFAR4 (0.38) | FFAR4CETPMMEACEUSP30 | |
| SCHEMBL18027484 | 0.87 | FFAR4 (0.39) | FFAR4MMEACEFASN | |
| SCHEMBL24380848 | 0.86 | FFAR4 (0.36) | FFAR4MMEACEPAK1 | |
| SCHEMBL16941493 | 0.84 | F10 (0.36) | FFAR4MMEUSP30FASNGPR119 | |
| SCHEMBL16930524 | 0.84 | USP30 (0.36) | FFAR4MMEACEUSP30FASN | |
| SCHEMBL16930525 | 0.84 | USP30 (0.36) | FFAR4MMEACEUSP30FASN | |
| SCHEMBL16941560 | 0.83 | FASN (0.38) | FASNGPR119CYP3A4CYP3A5PAK1 | |
| SCHEMBL598255 | 0.82 | KLK7 (0.45) | CETPUSP30 | |
| SCHEMBL1908567 | 0.82 | KLK7 (0.45) | CETPUSP30 | |
| SCHEMBL598389 | 0.82 | KLK7 (0.45) | CETPUSP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3256446-B1 | (2S,4R)-5-(5'-CHLORO-2'-FLUOROBIPHENYL-4-YL)-4-(ETHOXYOXALYLAMINO)-2-HYDROXYMETHYL-2-METHYLPENTANOIC ACID AS NEPRILYSIN INHIBITOR | THERAVANCE BIOPHARMA R&D IP LLC (US) | 2022-05-18 | — | — | EP | disclosed |