Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 15/20 | 0.59 |
| ▸ | ACE | P12821 | 4/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 2/20 | 0.41 |
| ▸ | CTSK | P43235 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19696010 | 0.91 | MME (0.60) | MMEACE | |
| SCHEMBL19086104 | 0.91 | MME (0.60) | MMEACE | |
| SCHEMBL15474326 | 0.91 | MME (0.60) | MMEACE | |
| SCHEMBL15467872 | 0.87 | MME (0.76) | MMEACEATMCTSSCTSK | |
| SCHEMBL19665458 | 0.87 | MME (0.76) | MMEACEATMCTSSCTSK | |
| SCHEMBL19665459 | 0.87 | MME (0.76) | MMEACEATMCTSSCTSK | |
| SCHEMBL19688029 | 0.83 | MME (0.51) | MMEACE | |
| SCHEMBL18922667 | 0.83 | MME (0.51) | MMEACE | |
| SCHEMBL18286815 | 0.83 | MME (0.51) | MMEACE | |
| SCHEMBL22389976 | 0.83 | MME (0.73) | MMEACEATMCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3256446-B1 | (2S,4R)-5-(5'-CHLORO-2'-FLUOROBIPHENYL-4-YL)-4-(ETHOXYOXALYLAMINO)-2-HYDROXYMETHYL-2-METHYLPENTANOIC ACID AS NEPRILYSIN INHIBITOR | THERAVANCE BIOPHARMA R&D IP LLC (US) | 2022-05-18 | — | — | EP | disclosed |