Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.55 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.51 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.51 |
| ▸ | IDO1 | P14902 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | CTSS | P25774 | 2/20 | 0.44 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KLK7 | P49862 | 1/20 | 0.44 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24593936 | 0.85 | SYK (0.57) | SYKSLC1A3SLC1A1IDO1MAPT | |
| SCHEMBL17860787 | 0.85 | SYK (0.57) | SYKSLC1A3SLC1A1IDO1MAPT | |
| SCHEMBL17878734 | 0.84 | SYK (0.56) | SYKSLC1A3SLC1A1IDO1MAPT | |
| SCHEMBL6619899 | 0.83 | SYK (0.68) | SYKSLC1A3SLC1A1IDO1MAPT | |
| SCHEMBL14360855 | 0.83 | SYK (0.68) | SYKSLC1A3SLC1A1IDO1MAPT | |
| SCHEMBL19057326 | 0.83 | SYK (0.68) | SYKSLC1A3SLC1A1IDO1MAPT | |
| SCHEMBL1627707 | 0.83 | SYK (0.67) | SYKIDO1MAPTL3MBTL1MEN1 | |
| SCHEMBL4142820 | 0.83 | SYK (0.55) | SYKSLC1A3SLC1A1IDO1MAPT | |
| SCHEMBL5441822 | 0.82 | SYK (0.63) | SYKSLC1A3SLC1A1IDO1MAPT | |
| SCHEMBL16274170 | 0.82 | SYK (0.63) | SYKIDO1MAPTL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3256446-B1 | (2S,4R)-5-(5'-CHLORO-2'-FLUOROBIPHENYL-4-YL)-4-(ETHOXYOXALYLAMINO)-2-HYDROXYMETHYL-2-METHYLPENTANOIC ACID AS NEPRILYSIN INHIBITOR | THERAVANCE BIOPHARMA R&D IP LLC (US) | 2022-05-18 | — | — | EP | disclosed |