Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13145353 | 0.80 | SMN1; SMN2 (0.69) | SMN1; SMN2HTTL3MBTL1KDM4EPOLB | |
| SCHEMBL21941854 | 0.80 | SMN1; SMN2 (0.69) | SMN1; SMN2HTTL3MBTL1KDM4EPOLB | |
| SCHEMBL21743267 | 0.80 | SMN1; SMN2 (0.69) | SMN1; SMN2HTTL3MBTL1KDM4EPOLB | |
| SCHEMBL13145355 | 0.79 | SMN1; SMN2 (0.67) | SMN1; SMN2KDM4EPOLBKMT2AMEN1 | |
| SCHEMBL21743274 | 0.77 | SMN1; SMN2 (0.69) | SMN1; SMN2HTTL3MBTL1KDM4EPOLB | |
| SCHEMBL18747350 | 0.77 | SMN1; SMN2 (0.69) | SMN1; SMN2HTTL3MBTL1KDM4EPOLB | |
| SCHEMBL23641970 | 0.77 | SMN1; SMN2 (0.69) | SMN1; SMN2HTTL3MBTL1KDM4EPOLB | |
| SCHEMBL22890900 | 0.74 | SLC6A2 (0.34) | SMN1; SMN2MAPK1KDM4E | |
| SCHEMBL3966966 | 0.73 | SMN1; SMN2 (0.73) | SMN1; SMN2L3MBTL1KDM4EPOLBKMT2A | |
| SCHEMBL3970208 | 0.73 | SMN1; SMN2 (0.73) | SMN1; SMN2L3MBTL1KDM4EPOLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3519393-B1 | SUBSTITUTED FUSED BI- OR TRI- HETEROCYCLIC COMPOUNDS AS EHMT2 INHIBITORS | EPIZYME INC (US) | 2022-05-18 | — | — | EP | disclosed |