Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 4/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | MME | P08473 | 3/20 | 0.34 |
| ▸ | ACE | P12821 | 1/20 | 0.34 |
| ▸ | GHSR | Q92847 | 1/20 | 0.34 |
| ▸ | FASN | P49327 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20364012 | 0.84 | MAOB (0.39) | ROCK2FFAR4ROCK1MAOBHTR2A | |
| SCHEMBL20364020 | 0.82 | MME (0.36) | ROCK2FFAR4ROCK1MAOBMME | |
| SCHEMBL24380861 | 0.82 | MME (0.36) | ROCK2FFAR4ROCK1MAOBMME | |
| SCHEMBL16979073 | 0.80 | CHRM1 (0.37) | ROCK2FFAR4MAOBHTR2AFASN | |
| SCHEMBL16979069 | 0.78 | KCNA5 (0.43) | ROCK2MAOB | |
| SCHEMBL10847469 | 0.78 | GAA (0.48) | GHSR | |
| SCHEMBL8283063 | 0.78 | GAA (0.48) | GHSR | |
| SCHEMBL1908538 | 0.75 | GRM2 (0.40) | ROCK2GRM2 | |
| SCHEMBL20072321 | 0.75 | GRM2 (0.40) | ROCK2GRM2 | |
| SCHEMBL4440151 | 0.75 | GRM2 (0.40) | ROCK2GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3256446-B1 | (2S,4R)-5-(5'-CHLORO-2'-FLUOROBIPHENYL-4-YL)-4-(ETHOXYOXALYLAMINO)-2-HYDROXYMETHYL-2-METHYLPENTANOIC ACID AS NEPRILYSIN INHIBITOR | THERAVANCE BIOPHARMA R&D IP LLC (US) | 2022-05-18 | — | — | EP | disclosed |