SCHEMBL2443201

SCHEMBL2443201

Cc1cccc(-c2sc(C)nc2C(=O)N2CC3CC(C)C[C@@H]3C2CNC(=O)c2cccc3c2OCCO3)c1

nearest known ligand 0.57

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HCRTR1 O43613 20/20 0.57
HCRTR2 O43614 15/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL496617 1.00 HCRTR1 (0.57) HCRTR1HCRTR2
SCHEMBL1339083 0.96 HCRTR1 (0.60) HCRTR1HCRTR2
SCHEMBL496546 0.91 HCRTR1 (0.64) HCRTR1HCRTR2
SCHEMBL2477357 0.91 HCRTR1 (0.64) HCRTR1HCRTR2
SCHEMBL2444525 0.90 HCRTR1 (0.47) HCRTR1HCRTR2
SCHEMBL1339107 0.89 HCRTR1 (0.54) HCRTR1HCRTR2
SCHEMBL496582 0.88 HCRTR1 (0.58) HCRTR1HCRTR2
SCHEMBL1339647 0.87 HCRTR1 (0.54) HCRTR1HCRTR2
SCHEMBL1338831 0.87 HCRTR1 (0.59) HCRTR1HCRTR2
SCHEMBL496130 0.86 HCRTR1 (0.64) HCRTR1HCRTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2164847-B1 3-AZA-BICYCLO[3.3.0]OCTANE COMPOUNDS ACTELION PHARMACEUTICALS LTD (CH) 2011-09-14 EP disclosed