Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.60 |
| ▸ | TP53 | P04637 | 7/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.42 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.40 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2442472 | 0.87 | TP53 (0.66) | SMN1; SMN2TP53MAPTALOX15TSHR | |
| SCHEMBL2442817 | 0.87 | SMN1; SMN2 (0.76) | SMN1; SMN2TP53MAPTMEN1KMT2A | |
| SCHEMBL2443302 | 0.78 | TP53 (0.74) | SMN1; SMN2TP53MAPTALOX15TSHR | |
| SCHEMBL2439106 | 0.77 | SMN1; SMN2 (0.58) | SMN1; SMN2TP53MAPTMEN1KMT2A | |
| SCHEMBL2438649 | 0.76 | SMN1; SMN2 (0.54) | SMN1; SMN2TP53MAPTKMT2ACSF1R | |
| SCHEMBL2439676 | 0.76 | TP53 (0.54) | SMN1; SMN2TP53MAPTMAOBMEN1 | |
| SCHEMBL2442316 | 0.75 | TP53 (1.00) | SMN1; SMN2TP53MAPTMEN1KMT2A | |
| SCHEMBL2439755 | 0.73 | TP53 (0.66) | SMN1; SMN2TP53MAPTALOX15TSHR | |
| SCHEMBL2441769 | 0.73 | MEN1 (0.48) | SMN1; SMN2TP53MAPTACHEMAOB | |
| SCHEMBL2438675 | 0.72 | TP53 (0.82) | SMN1; SMN2TP53MAPTALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893589-B1 | SUBSTITUTED N-BENZO [D] ISOXAZOL-3-YL-AMINE DERIVATIVES AS INHIBITORS OF MGLUR5, SEROTONINE (5-HT) AND NORADRENALINE RECEPTORS, AND THE USE THEREOF FOR PRODUCING MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2011-09-14 | — | — | EP | claimed |