Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperacillin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.77 |
| ▸ | CCKBR | P32239 | 1/20 | 0.77 |
| ▸ | LMNA | P02545 | 3/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | RECQL | P46063 | 3/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | TEK | Q02763 | 1/20 | 0.59 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | CA1 | P00915 | 8/20 | 0.58 |
| ▸ | CA2 | P00918 | 8/20 | 0.58 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperacillin SCHEMBL27343970 | 1.00 | MEN1 (0.77) | MEN1KMT2ACCKBRLMNAKDM4E | |
| Piperacillin SCHEMBL10477435 | 1.00 | MEN1 (0.77) | MEN1KMT2ACCKBRLMNAKDM4E | |
| Piperacillin SCHEMBL13788683 | 1.00 | MEN1 (0.77) | MEN1KMT2ACCKBRLMNAKDM4E | |
| Piperacillin SCHEMBL13788684 | 1.00 | MEN1 (0.77) | MEN1KMT2ACCKBRLMNAKDM4E | |
| Piperacillin SCHEMBL11908507 | 1.00 | MEN1 (0.77) | MEN1KMT2ACCKBRLMNAKDM4E | |
| Piperacillin SCHEMBL33894 | 1.00 | MEN1 (0.77) | MEN1KMT2ACCKBRLMNAKDM4E | |
| Piperacillin SCHEMBL3233001 | 1.00 | MEN1 (0.77) | MEN1KMT2ACCKBRLMNAKDM4E | |
| Piperacillin SCHEMBL4486297 | 1.00 | MEN1 (0.77) | MEN1KMT2ACCKBRLMNAKDM4E | |
| Piperacillin SCHEMBL14506140 | 1.00 | MEN1 (0.77) | MEN1KMT2ACCKBRLMNAKDM4E | |
| Piperacillin SCHEMBL41302 | 0.99 | MEN1 (0.76) | MEN1KMT2ACCKBRLMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220154244-A1 | BIOCIDE COMPOSITIONS COMPATIBLE WITH ENZYME BIOSENSORS AND METHODS OF USE THEREOF | INSTRUMENTATION LABORATORY COMPANY | 2022-05-19 | — | — | US | disclosed |