Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.53 |
| ▸ | TTK | P33981 | 10/20 | 0.41 |
| ▸ | RET | P07949 | 5/20 | 0.38 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.37 |
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | WNT1 | P04628 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24438647 | 0.79 | DYRK1A (0.43) | GSK3BDYRK1ATTKRETCCNA2 | |
| SCHEMBL27170240 | 0.77 | BTK (0.54) | GSK3BDYRK1ATTKRETCCNA2 | |
| SCHEMBL24437819 | 0.77 | BTK (0.54) | GSK3BDYRK1ATTKRETCCNA2 | |
| SCHEMBL27170238 | 0.77 | BTK (0.54) | GSK3BDYRK1ATTKRETCCNA2 | |
| SCHEMBL25236672 | 0.76 | CHEK1 (0.39) | KDRIRAK4 | |
| SCHEMBL17801236 | 0.74 | CHEK1 (0.47) | IRAK4 | |
| SCHEMBL20967198 | 0.74 | DYRK1A (0.75) | GSK3BDYRK1AWNT1 | |
| SCHEMBL19253504 | 0.74 | JAK2 (0.48) | KDR | |
| SCHEMBL24438255 | 0.73 | JAK2 (0.41) | TTKAURKAKDR | |
| SCHEMBL24060899 | 0.72 | ERN1 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022104079-A1 | PYRAZOLO[1,5-A]PYRAZINE DERIVATIVES AS BTK INHIBITORS | BIOGEN MA INC. (US) | 2022-05-19 | — | — | WO | disclosed |