Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 4/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 3/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | PIM1 | P11309 | 3/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.39 |
| ▸ | RET | P07949 | 3/20 | 0.38 |
| ▸ | GSK3B | P49841 | 3/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.38 |
| ▸ | WNT1 | P04628 | 2/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24437657 | 0.89 | BTK (0.43) | BTKSYKAURKBPIM1PIM3 | |
| SCHEMBL24438239 | 0.86 | BTK (0.41) | BTKSYKAURKBPIM1PIM3 | |
| SCHEMBL24437858 | 0.86 | RET (0.51) | RET | |
| SCHEMBL24438356 | 0.82 | BTK (0.63) | BTKJAK2JAK1TYK2PIM1 | |
| SCHEMBL29674222 | 0.82 | BTK (0.63) | BTKJAK2JAK1TYK2PIM1 | |
| SCHEMBL24438184 | 0.82 | BTK (0.63) | BTKJAK2JAK1TYK2PIM1 | |
| SCHEMBL24438199 | 0.82 | BTK (0.43) | BTKJAK2JAK1TYK2SYK | |
| SCHEMBL24437823 | 0.79 | BTK (0.45) | BTKSYKAURKBPIM1PIM3 | |
| Hydrochloric Acid SCHEMBL29674208 | 0.79 | BTK (0.45) | BTKSYKAURKBPIM1PIM3 | |
| SCHEMBL24437678 | 0.78 | JAK1 (0.43) | BTKJAK2JAK1TYK2SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022104079-A1 | PYRAZOLO[1,5-A]PYRAZINE DERIVATIVES AS BTK INHIBITORS | BIOGEN MA INC. (US) | 2022-05-19 | — | — | WO | disclosed |