Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 5/20 | 0.40 |
| ▸ | ABCC3 | O15438 | 2/20 | 0.37 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.37 |
| ▸ | SLCO1B3 | Q9NPD5 | 2/20 | 0.37 |
| ▸ | SLCO1B1 | Q9Y6L6 | 2/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.33 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.33 |
| ▸ | PDE4A | P27815 | 2/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.33 |
| ▸ | TMPRSS15 | P98073 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24439392 | 1.00 | LPAR1 (0.40) | LPAR1ABCC3ABCC4SLCO1B3SLCO1B1 | |
| SCHEMBL29517764 | 1.00 | LPAR1 (0.40) | LPAR1ABCC3ABCC4SLCO1B3SLCO1B1 | |
| SCHEMBL29577128 | 0.91 | LPAR1 (0.41) | LPAR1ABCC3ABCC4SLCO1B3SLCO1B1 | |
| SCHEMBL28744990 | 0.91 | LPAR1 (0.46) | LPAR1ABCC3ABCC4SLCO1B3SLCO1B1 | |
| SCHEMBL24441674 | 0.91 | LPAR1 (0.41) | LPAR1ABCC3ABCC4SLCO1B3SLCO1B1 | |
| SCHEMBL24441049 | 0.89 | LPAR1 (0.40) | LPAR1ABCC3ABCC4SLCO1B3SLCO1B1 | |
| SCHEMBL29576333 | 0.89 | LPAR1 (0.40) | LPAR1ABCC3ABCC4SLCO1B3SLCO1B1 | |
| SCHEMBL24440690 | 0.89 | LPAR1 (0.40) | LPAR1ABCC3ABCC4SLCO1B3SLCO1B1 | |
| SCHEMBL29576361 | 0.89 | LPAR1 (0.40) | LPAR1ABCC3ABCC4SLCO1B3SLCO1B1 | |
| SCHEMBL24439618 | 0.87 | LPAR1 (0.41) | LPAR1ABCC3ABCC4SLCO1B3SLCO1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022100624-A1 | OXY-SUBSTITUTED AMINOCARBONATE THIOPHENE-BASED COMPOUND AND USE THEREOF | 武汉人福创新药物研发中心有限公司 | 2022-05-19 | — | — | WO | disclosed |
| WO-2022100623-A1 | NITROGEN-SUBSTITUTED HETEROCYCLIC THIOPHENE COMPOUNDS AND USE THEREOF | 武汉人福创新药物研发中心有限公司 | 2022-05-19 | — | — | WO | disclosed |
| WO-2022100623-A1 | NITROGEN-SUBSTITUTED HETEROCYCLIC THIOPHENE COMPOUNDS AND USE THEREOF | 武汉人福创新药物研发中心有限公司 | 2022-05-19 | — | — | WO | disclosed |
| CN-114456159-A | Nitrogen-substituted heterocyclic thiophene compound and application thereof | 武汉人福创新药物研发中心有限公司 | 2022-05-10 | — | — | CN | disclosed |