Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 5/20 | 0.37 |
| ▸ | MAP2K1 | Q02750 | 9/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15216750 | 0.84 | NPC1 (0.45) | NPC1RAB9ASMN1; SMN2IGF1RMAP2K1 | |
| SCHEMBL15208567 | 0.78 | IGF1R (0.43) | IGF1RMAP2K1KDREGFR | |
| SCHEMBL23678 | 0.78 | IGF1R (0.44) | IGF1RMAP2K1 | |
| SCHEMBL15216751 | 0.76 | IGF1R (0.44) | IGF1RMAP2K1LMNAUSP2ALDH1A1 | |
| SCHEMBL15206974 | 0.74 | NPC1 (0.43) | NPC1RAB9ASMN1; SMN2IGF1RMAP2K1 | |
| SCHEMBL24518 | 0.74 | GCK (0.44) | SMN1; SMN2IGF1RMAP2K1ALDH1A1TP53 | |
| SCHEMBL24626 | 0.73 | IGF1R (0.37) | NPC1RAB9ASMN1; SMN2IGF1RMAP2K1 | |
| SCHEMBL15206972 | 0.72 | NPC1 (0.43) | NPC1RAB9ASMN1; SMN2IGF1RMAP2K1 | |
| SCHEMBL24060 | 0.70 | IGF1R (0.47) | NPC1RAB9AIGF1RMAP2K1EGFR | |
| SCHEMBL24767 | 0.70 | IGF1R (0.47) | NPC1RAB9AIGF1RMAP2K1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012025186-A1 | TRIAZOLOPYRAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-03-01 | — | — | WO | disclosed |