Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 13/20 | 0.47 |
| ▸ | PDCD1 | Q15116 | 5/20 | 0.45 |
| ▸ | VSIR | Q9H7M9 | 4/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19916357 | 1.00 | CD274 (0.47) | CD274PDCD1VSIRCYP2D6CYP2C19 | |
| SCHEMBL29615339 | 0.96 | CD274 (0.48) | CD274PDCD1VSIRALDH1A1KDM4E | |
| SCHEMBL19897792 | 0.96 | CD274 (0.48) | CD274PDCD1VSIRALDH1A1KDM4E | |
| SCHEMBL24445439 | 0.95 | CD274 (0.49) | CD274PDCD1VSIRCYP2D6CYP2C19 | |
| SCHEMBL19916135 | 0.95 | CD274 (0.49) | CD274PDCD1VSIRCYP2D6CYP2C19 | |
| SCHEMBL19939882 | 0.93 | CD274 (0.44) | CD274PDCD1VSIRALDH1A1HTT | |
| SCHEMBL19939388 | 0.93 | CD274 (0.45) | CD274PDCD1VSIRALDH1A1KDM4E | |
| SCHEMBL19939496 | 0.93 | CD274 (0.45) | CD274PDCD1VSIRALDH1A1KDM4E | |
| SCHEMBL24445446 | 0.91 | CD274 (0.46) | CD274PDCD1VSIRALDH1A1KDM4E | |
| SCHEMBL19897864 | 0.91 | CD274 (0.49) | CD274PDCD1VSIRALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3507284-B1 | BIARYL COMPOUNDS USEFUL AS IMMUNOMODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2022-05-25 | — | — | EP | disclosed |