SCHEMBL24445909

SCHEMBL24445909

COC(=O)c1cc(O)ccc1OC(F)(F)F

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 3/20 0.57
CA1 P00915 3/20 0.57
CA2 P00918 3/20 0.57
CA7 P43166 3/20 0.57
CA9 Q16790 3/20 0.57
CA14 Q9ULX7 3/20 0.57
PDK2 Q15119 1/20 0.53
PDK4 Q16654 1/20 0.53
EGFR P00533 3/20 0.45
KCNK3 O14649 3/20 0.44
KCNK9 Q9NPC2 3/20 0.44
MBOAT4 Q96T53 1/20 0.43
CFTR P13569 1/20 0.42
EPHX2 P34913 1/20 0.42
APP P05067 2/20 0.41
PTGS2 P35354 1/20 0.41
MRGPRX4 Q96LA9 1/20 0.41
AR P10275 1/20 0.40
LMNA P02545 1/20 0.40
TSHR P16473 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21842996 0.87 CA12 (0.57) CA12CA1CA2CA7CA9
SCHEMBL24436713 0.83 KCNK3 (0.43) CA12CA1CA2CA7CA9
SCHEMBL654962 0.83 GAA (0.53) KCNK3KCNK9MBOAT4CFTREPHX2
SCHEMBL30694764 0.83 HSD17B10 (0.51) KCNK3KCNK9MBOAT4CFTREPHX2
SCHEMBL3943968 0.83 HSD17B10 (0.51) KCNK3KCNK9MBOAT4CFTREPHX2
SCHEMBL30843111 0.83 ABL1 (0.51) PDK2KCNK3KCNK9MRGPRX4LMNA
SCHEMBL24436790 0.82 MRGPRX4 (0.40) CA12CA1CA2CA7CA9
SCHEMBL27051469 0.81 CA12 (0.50) CA12CA1CA2CA7CA9
SCHEMBL24269594 0.81 EPHX2 (0.47) EGFRKCNK3KCNK9MBOAT4CFTR
SCHEMBL7619139 0.81 CA12 (0.67) CA12CA1CA2CA7CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4001336-A1 POLYURETHANE, POLYURETHANE PRODUCTION METHOD, CONDUCTIVE PASTE COMPOSITION, CONDUCTIVE WIRE, AND METHOD FOR PRODUCING CONDUCTIVE WIRE Shin-Etsu Chemical Co., Ltd. (JP) 2022-05-25 EP disclosed