Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.37 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.37 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
| ▸ | CCR8 | P51685 | 1/20 | 0.36 |
| ▸ | METAP1 | P53582 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2055586 | 0.81 | SMN1; SMN2 (0.50) | SMN1; SMN2L3MBTL1HDAC6CHRM2IMPDH2 | |
| SCHEMBL5561478 | 0.78 | SMN1; SMN2 (0.52) | SMN1; SMN2L3MBTL1HDAC6CHRM2HDAC8 | |
| SCHEMBL19862563 | 0.78 | SMN1; SMN2 (0.47) | SMN1; SMN2L3MBTL1HDAC6CHRM2IMPDH2 | |
| SCHEMBL24451411 | 0.76 | SMN1; SMN2 (0.45) | SMN1; SMN2L3MBTL1HDAC6CHRM2IMPDH2 | |
| SCHEMBL29080 | 0.75 | SMN1; SMN2 (0.58) | SMN1; SMN2L3MBTL1CHRM2HDAC8EHMT2 | |
| SCHEMBL31645911 | 0.75 | SMN1; SMN2 (0.58) | SMN1; SMN2L3MBTL1CHRM2HDAC8EHMT2 | |
| SCHEMBL10356935 | 0.75 | SMN1; SMN2 (0.58) | SMN1; SMN2L3MBTL1CHRM2HDAC8EHMT2 | |
| SCHEMBL29349628 | 0.75 | SMN1; SMN2 (0.58) | SMN1; SMN2L3MBTL1CHRM2HDAC8EHMT2 | |
| SCHEMBL28883610 | 0.75 | SMN1; SMN2 (0.58) | SMN1; SMN2L3MBTL1CHRM2HDAC8EHMT2 | |
| SCHEMBL20840547 | 0.75 | SMN1; SMN2 (0.44) | SMN1; SMN2L3MBTL1HDAC6CHRM2IMPDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220402926-A1 | NOVEL MACROCYCLIC SPIROPYRROLIDINE DERIVED ANTIVIRAL AGENTS | ENANTA PHARMACEUTICALS, INC. | 2022-12-22 | — | — | US | disclosed |
| US-20220162231-A1 | NOVEL SPIROPYRROLIDINE DERIVED ANTIVIRAL AGENTS | ENANTA PHARMACEUTICALS, INC. | 2022-05-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220402926-A1 | NOVEL MACROCYCLIC SPIROPYRROLIDINE DERIVED ANTIVIRAL AGENTS | ACE, ACE2, PKD1 | SMN1; SMN2 2757/4885L3MBTL1 4797/4885HDAC6 36/4885 |
| US-20220162231-A1 | NOVEL SPIROPYRROLIDINE DERIVED ANTIVIRAL AGENTS | ACE, ACE2, PKD1 | SMN1; SMN2 3361/4885L3MBTL1 4851/4885HDAC6 51/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.