Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUCY1A1 | Q02108 | 20/20 | 0.64 |
| ▸ | GUCY1B1 | Q02153 | 20/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 10/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2441717 | 0.90 | GUCY1A1 (0.66) | GUCY1A1GUCY1B1KCNH2 | |
| SCHEMBL14481987 | 0.84 | GUCY1A1 (0.69) | GUCY1A1GUCY1B1KCNH2 | |
| SCHEMBL14481807 | 0.82 | GUCY1A1 (0.67) | GUCY1A1GUCY1B1KCNH2 | |
| SCHEMBL2515924 | 0.82 | GUCY1A1 (0.55) | GUCY1A1GUCY1B1KCNH2 | |
| SCHEMBL14549806 | 0.81 | GUCY1A1 (0.68) | GUCY1A1GUCY1B1KCNH2 | |
| SCHEMBL14481809 | 0.80 | GUCY1A1 (0.82) | GUCY1A1GUCY1B1KCNH2 | |
| SCHEMBL12322395 | 0.80 | GUCY1A1 (0.73) | GUCY1A1GUCY1B1KCNH2 | |
| SCHEMBL2499892 | 0.80 | GUCY1A1 (0.53) | GUCY1A1GUCY1B1KCNH2 | |
| SCHEMBL2445297 | 0.79 | GUCY1A1 (0.65) | GUCY1A1GUCY1B1KCNH2 | |
| SCHEMBL2441721 | 0.79 | GUCY1A1 (0.70) | GUCY1A1GUCY1B1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011119518-A1 | SOLUBLE GUANYLATE CYCLASE ACTIVATORS | MERCK SHARP & DOHME CORP. (US) | 2011-09-29 | — | — | WO | claimed |
| WO-2011119518-A1 | SOLUBLE GUANYLATE CYCLASE ACTIVATORS | MERCK SHARP & DOHME CORP. (US) | 2011-09-29 | — | — | WO | disclosed |